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Life Sciences - Health - 04.10.2017
Cell death by necrosis is not an accidental process
Cell death by necrosis is not an accidental process
Drosophila testes visualized by confocal microscopy. Necrotic germ cells are visualized in red (white arrowheads), cell nuclei in blue. Victor Girard Cell death allows elimination of supernumerary cells during development or of abnormal cells throughout life. Physiological cell death is tightly regulated to prevent pathologies such as degenerative diseases or cancers, which often occur due to excessive or absent cell death, respectively.

Health - Psychology - 02.10.2017
Prenatal exposure to endocrine disruptors and behavioral problems in children
An epidemiological study carried out by Inserm on families from the EDEN cohort (500 boys born between 2003 and 2006 and their mothers) shows that exposure during pregnancy to certain phenols and phthalates is associated with behavioral problems in boys between 3 and 5 years of age. The most worrying compounds in this respect are bisphenol A, triclosan and dibutyl phthalate (DBP).

Health - Life Sciences - 28.09.2017
How do arteries protect themselves from atherosclerosis?
Associated with an aging population and the development of metabolic syndrome, atherosclerosis is a leading cause of death worldwide. Researchers from Inserm Unit 970, the "Paris Cardiovascular Research Center" (Inserm/Université Paris Descartes), have succeeded in revealing the mechanisms underlying the formation of atherosclerotic plaques.

Health - Life Sciences - 21.09.2017
"Humanized" Mouse Model Developed to Study Hepatitis B Infection
The ANRS consortium "Humanized Mouse Models for Viral Hepatitis"1, made up of 6 teams of researchers, has developed a mouse model for studying the interaction between the immune system and the liver following infection by the hepatitis B virus. This research, coordinated by Dr. Hélène Strick-Marchand (Inserm joint unit 1223, "Physiopathology of the Immune System", Institut Pasteur), responds to a real lack of animal models for studying this disease and thus opens up the possibilities for evaluating new therapeutic strategies.

Health - 13.09.2017
Researchers Warn About Mixtures of Endocrine Disruptors During Pregnancy
A new study led by Inserm researchers from Irset, the Research Institute for Environmental and Occupational Health, [1 ] shows for the first time in humans that simultaneous exposure to endocrine disruptors exacerbates the effects observed from exposure to each chemical independently. This study focused principally on the human fetal testes and the potential consequences of these mixtures on development of the reproductive system, as the selected chemicals inhibited testosterone production.

Health - Life Sciences - 08.09.2017
Animal welfare : Potential new indicator of chronic stress in horses
Animal welfare : Potential new indicator of chronic stress in horses
Cortisol is generally considered to be a stress hormone because its levels rise during episodes of acute stress. Yet its relationship to chronic stress is less clear. Researchers from the Éthologie Animale et Humaine laboratory (CNRS / Université de Rennes 1 /Université of Caen) and the Research Institute for Environmental and Occupational Health (INSERM /Université de Rennes 1), in collaboration with the University of Veterinary Medicine in Vienna, have linked lower cortisol levels to states of chronically poor welfare in adult horses observed under their usual living conditions.

Health - 04.09.2017
Schizophrenia: the link between personality disorders and the perception of time
A recent study conducted by Anne Giersch and her team of researchers (Inserm Unit 1114 /University of Strasbourg) showed that some people with schizophrenia are unable to perceive and anticipate the passage of time. These results, published in the Scientific Reports journal, also reveal a link between fragile temporal prediction and minimal self disorders (self-perception, "I am here, now").

Life Sciences - Health - 01.09.2017
The bacteria responsible for Legionellosis modulates the host cell metabolism to its advantage
The bacteria responsible for Legionellosis modulates the host cell metabolism to its advantage
Scientists at the Institut Pasteur, CNRS and Inserm, together with a team from Switzerland*, have shown that the bacterial pathogen Legionella pneumophila (the causative agent of Legionnaires' disease or legionellosis) has developed a specific strategy to target the host cell mitochondria, the organelles in charge of cellular bioenergetics.

Life Sciences - Health - 11.08.2017
Testicular macrophages are guardians of fertility
Testicular macrophages are guardians of fertility
The origin, development, and characteristics of two types of testicular macrophage have been described by a CNRS team at the Centre d'Immunologie de Marseille-Luminy (CNRS / INSERM / Aix-Marseille University). To elucidate the nature of these immune cells, the researchers used a novel cell tracing method.

Life Sciences - Health - 09.08.2017
Testicular macrophages are guardians of fertility
The origin, development, and characteristics of two types of testicular macrophage have been described by a CNRS team at the Centre d'Immunologie de Marseille-Luminy (CNRS / INSERM / Aix-Marseille University). To elucidate the nature of these immune cells, the researchers used a novel cell tracing method.

Health - Life Sciences - 25.07.2017
Microdystrophin restores muscle strength in Duchenne muscular dystrophy
Researchers from Généthon, the AFM-Téléthon laboratory, Inserm (UMR 1089, Nantes) and the University of London (Royal Holloway) demonstrated the efficacy of an innovative gene therapy in the treatment of Duchenne muscular dystrophy. Indeed, after injecting microdystrophin (a "shortened" version of the dystrophin gene) via a drug vector, the researchers managed to restore muscle strength and stabilise the clinical symptoms in dogs naturally affected by Duchenne muscular dystrophy.

Health - Life Sciences - 20.07.2017
Gene therapy: first results in children with Sanfilippo B syndrome
On July 13, 2017, the journal Lancet Neurology published the results of a gene therapy trial conducted in four children with Sanfilippo type B syndrome (also known as MPS IIIB). This trial is the achievement of a two-decade partnership with financial support of AFM-Téléthon and the cooperation of the charity "Vaincre les Maladies Lysosomales" (VML).

Chemistry - Health - 19.07.2017
Navelbine and Taxotere : Histories of Sciences
Navelbine and Taxotere : Histories of Sciences
Weaving history with chemistry, Navelbine and Taxotere : Histories of Sciences (ISTE Editions, June 2017) tells the story of two anticancer drugs—both of natural origin—discovered by teams of researchers at the CNRS Institut de Chimie des Substances Naturelles (ICSN).

Health - Life Sciences - 12.07.2017
Phage therapy : synergy between bacteriophages and the immune system is essential
Phage therapy involves the use of bacteriophages, or phages, for treating bacterial infections. Phages are viruses that specifically attack bacteria and are harmless to humans. A significant decline in the use of this therapeutic strategy introduced 100 years ago was seen in the West following the development of antibiotics.

Health - Life Sciences - 03.07.2017
A major advance towards a treatment for accelerated ageing
In a study published today in the journal EMBO Molecular Medicine1, the team led by Prof. Nicolas Lévy identifies the mechanism associated with the accumulation of progerin, a toxic protein produced in the course of ageing, and demonstrates the therapeutic potential of a new drug - MG132 - to treat progeria, a rare syndrome involving premature and accelerated ageing.

Life Sciences - Health - 23.06.2017
Omega-3 Essential for the Brain from Adolescence into Adulthood
Omega-3 fatty acids are crucial for the brain. Deficiency in these acids can lead to depressive mood. A new study led by Inserm and Inra researchers from Unit 901, 'Mediterranean Institute of Neurobiology' (Inserm/Université d'Aix-Marseille) and UMR 1256, 'Nutrition and Integrated Neurobiology' (Inra/Université de Bordeaux) reveals the mechanisms of disease that develop in adult mice on a low omega-3 diet since adolescence.

Life Sciences - Health - 21.06.2017
Discovery of a new mechanism involved in the migration of cancer cells
A team of young researchers under the supervision of Guillaume Montagnac, Inserm research leader at Gustave Roussy, in collaboration with the Institut Curie and the Institut de Myologie ( Myology Institute ), has discovered a new mechanism which facilitates cell migration.

Health - Life Sciences - 19.06.2017
Neuronal Self-Defense Against Alzheimer’s Disease
It is known that IGF-1 ( insulin-like growth factor ) is needed for development and also plays a role throughout the body's life. Previously, the team led by Martin Holzenberger (Inserm/UPMC Unit 938, Saint-Antoine Research Center) has shown that this hormone is involved in longevity and in Alzheimer's disease.

Health - 13.06.2017
Prenatal stress affects life expectancy in offspring
Major prenatal stress reduces the lifespan of adult offspring by over 2 years. Inserm researchers have obtained these results by studying a cohort of children born between 1914 and 1916, some of whom lost their father in combat before they were even born. Stress suffered by the mother seems to weaken the fetus, at a developmental stage characterized by a high level of plasticity.

Health - Life Sciences - 12.06.2017
Blood test developed to detect rare neurological disease
Teams from the AP-HP Paris public hospitals network, in collaboration with researchers from the Brain & Spine Institute (ICM) (Inserm/CNRS/UPMC), and Metafora biosystems, a start-up with links to the CNRS, have recently developed a diagnostic blood test for a rare but treatable condition called De Vivo disease.
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