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Health - 02.06.2020
Promising initial results for a COVID-19 diagnostic test in saliva
Promising initial results for a COVID-19 diagnostic test in saliva
Scientists in the Sys2diag Laboratory (CNRS/ALCEN) and doctors from University Hospital (CHU) of Montpellier have presented the first results of a clinical trial on the EasyCov SARS-CoV-2 detection test. This shows satisfactory performance for a field test that solves a problem in situations where the RT-PCR test cannot be used.

Health - Mechanical Engineering - 06.05.2020
COVID-19: in uncommon times, dark matter specialists have applied their skills to ventilators
COVID-19: in uncommon times, dark matter specialists have applied their skills to ventilators
The Mechanical Ventilator Milano (MVM), an open source ventilator to support patients severely ill with COVID-19, has moved from design to reality in six weeks, propelled by physicists specialised in dark matter who turned their attention away from unknown particles for this period. It has just been authorised by the US Food and Drug Administration (FDA) as within the scope of the emergency use authorization for ventilators in intensive care.

Health - 05.05.2020
Scientists observe bacteria tumble their way out of surface traps
Scientists observe bacteria tumble their way out of surface traps
While tracing the movement of Escherichia coli, a team of French researchers noticed that near solid surfaces, the bacteria run in circles. Loop after loop, the tracing almost looks like an Olympic figure skating rink before the Zamboni irons the sheet of ice smooth. Breaking down E. coli's routine step by step, the scientists identified a signature move-surface tumbling.

Health - Pharmacology - 04.05.2020
Six new research projects concerning Covid-19
On April 10, 2020, ANR announced the funding of 86 projects concerning Covid-19. Six are associated with ENS de Lyon laboratories. The SARS-CoV-2 infection is a global emergency for human health. The interferon response is the body's first barrier to defending viral infections. This host response is initiated by the recognition of viral elements by receptor and leads to the production of molecules, including interferon, that alert surrounding cells.

Health - Life Sciences - 03.03.2020
Alzheimer's: Can an amino acid help to restore memories?
Alzheimer’s: Can an amino acid help to restore memories?
Scientists at the Laboratoire des Maladies Neurodégénératives (CNRS/CEA/Université Paris-Saclay) and the Neurocentre Magendie (INSERM/Université de Bordeaux) have just shown that a metabolic pathway plays a determining role in Alzheimer's disease's memory problems. This work, published on 3 March 2020 in Cell Metabolism, also shows that supplying a specific amino acid as a nutritional supplement in a mouse model of Alzheimer's restores spatial memory affected early.

Health - Linguistics / Literature - 11.12.2019
Speech could be older than we thought
Speech could be older than we thought
For 50 years, the theory of the "descended larynx" has stated that before speech can emerge, the larynx must be in a low position to produce differentiated vowels. Monkeys, which have a vocal tract anatomy that resembles that of humans in the essential articulators (tongue, jaw, lips) but with a higher larynx, could not produce differentiated vocalizations.

Life Sciences - Health - 24.09.2019
Disarming a probiotic to improve its benefits
Disarming a probiotic to improve its benefits
For more than a century, the Nissle 1917 strain of the bacterium Escherichia coli has been used as a probiotic to treat gastrointestinal disorders. However, this bacterium also produces a toxin, colibactin, which has deleterious effects on host DNA and might cause colon cancer. It is therefore crucial to understand the mechanisms at play in the strain if we wish to limit undesirable side effects.

Health - 05.08.2019
Enveloped viruses distinct from HBV induce dissemination of hepatitis D virus in vivo
Publication by the International Center for Infectiology Research (CIRI) on May 8, 2019. Hepatitis D virus (HDV) was discovered 40 years ago in the liver of individuals chronically infected with hepatitis B virus (HBV), a liver-specific human pathogen that provides its surface GPs to induce envelopment and secretion of HDV RNPs as well as transmission to other cells via HBV cell entry factors.

Life Sciences - Health - 25.07.2019
Artificial sweeteners: certain adverse metabolic effects revealed in a preclinical model
Artificial sweeteners: certain adverse metabolic effects revealed in a preclinical model
INRA researchers, in collaboration with the University of Adelaide, Australia, studied the effects that a widely used artificial sweetener blend, i.e. acesulfame K-sucralose, has on metabolism. For the first time, they revealed ' in animals ' an increase in glucose absorption, particularly in the brain and fatty tissues, indicating certain undesirable effects on metabolism and insulin sensitivity.

Health - 24.07.2019
Partially hydrolysed (hypoallergenic) baby formulas do not reduce allergy risks in infants
Partially hydrolysed (hypoallergenic) baby formulas do not reduce allergy risks in infants
Often, hypoallergenic formulas are recommended for infants who are not exclusively breastfed and who are at risk of developing allergies. While it is assumed that such formulas reduce the development of allergies later in life, it is unclear whether this claim is true. A team of INRA and INSERM researchers have shown that the consumption of partially hydrolysed (hypoallergenic) formulas was not associated with a reduced risk of developing allergies, findings that were recently published in the journal Pediatric Allergy and Immunology .

Pharmacology - Health - 10.07.2019
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in Familial Mediterranean Fever patients
Familial Mediterranean fever (FMF) is the most frequent hereditary systemic autoinflammatory syndrome. FMF is usually caused by bi-allelic mutations in the MEFV gene, encoding Pyrin. Conclusive genetic evidence lacks for about 30% of patients diagnosed with clinical FMF. Pyrin is an inflammasome sensor maintained inactive by two kinases (PKN1/2).

Environment - Health - 13.06.2019
Better air quality: what should the target values be for improving health?
Better air quality: what should the target values be for improving health?
To produce a significant reduction in mortality due to fine particulates, their average level should be reduced by at least 3 micrograms per m3 as a yearly average, concludes an interdisciplinary study led by researchers from Inserm, the CNRS, INRA, Atmo Auvergne Rhône-Alpes and the Université Grenoble Alpes.

Health - Agronomy / Food Science - 12.06.2019
The natural lipids in buttermilk could contribute to reducing cardiovascular risk in vulnerable populations
A French consortium led by INRA, in collaboration with INSERM, the Universities of Lyon and Clermont Auvergne, Lyon Civil Hospitals and the Human Nutrition Research Centres (CRNH) of Rhône-Alpes and Auvergne, have now demonstrated that consuming certain lipids present naturally in dairy products (called "polar lipids") could reduce the cardiovascular risk in overweight postmenopausal women by lowering their blood levels of LDL-cholesterol ("bad" cholesterol) and triglycerides.

Life Sciences - Health - 11.06.2019
Bluetongue virus can hijack the cellular machinery of its host
Bluetongue virus can hijack the cellular machinery of its host
Researchers at INRA, ANSES, and ENVA have discovered that bluetongue virus can enhance its replication by exploiting one of its host's cellular pathways. Published in the Journal of Virology , their results could help the quest to identify effective antiviral compounds for combating the virus. Bluetongue virus (BTV) can infect wild and domestic species of ruminants (ovines, caprines, and bovines).

Health - Agronomy / Food Science - 05.06.2019
Consumption of ultra-processed food and risk of cardiovascular disease
Consumption of ultra-processed food and risk of cardiovascular disease
In an article published May 30, 2019 in the British Medical Journal , researchers from Inserm, Inra, Université Paris 13 and Cnam in the Nutritional Epidemiology Research Team (EREN) report an increased risk of cardiovascular disease in consumers of ultra-processed foods in the NutriNet-Santé cohort.

Health - Environment - 20.03.2019
Encouraging a holistic approach in the fight against infectious diseases
Infectious diseases, the main causes of human mortality according to the WHO, have always been a particular concern for society. In a context of global change, the fight against infectious diseases remains a major challenge for the future and especially for Dominique Pontier and François-Loïc Cosset, researchers at the Université de Lyon.

Life Sciences - Health - 20.03.2019
Control of mosquito-borne diseases: discovery of a new genetic element in the Wolbachia bacterium
Control of mosquito-borne diseases: discovery of a new genetic element in the Wolbachia bacterium
Researchers from INRA, CIRAD, CEA, the University of Montpellier, and Chicago and Vanderbilt Universities in the United States have developed an innovative method for analysing the genome of the Wolbachia bacterium. This endosymbiotic* bacterium infects more than 70% of insects and is capable of influencing insect transmission of pathogens such as dengue or Zika virus.

Life Sciences - Health - 17.12.2018
Discovery of novel mechanisms that cause migraines
Discovery of novel mechanisms that cause migraines
PARIS, 17 december 2018 Researchers at CNRS, Université Côte d'Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. In fact, they found how a mutation, causes dysfunction in a protein which inhibits neuronal electrical activity, induces migraines. These results, published in Neuron on December 17, 2018, open a new path for the development of anti-migraine medicines.

Health - Agronomy / Food Science - 17.12.2018
A diet rich in cheese in early childhood may protect against allergies
A diet rich in cheese in early childhood may protect against allergies
A study conducted by the University Hospital of Besançon and INRA shows the protective effect of high cheese consumption from a very young age. For the first time, a link has been established between cheese consumption and the probability of developing food or skin allergic diseases, regardless of the consumption of various other foods (vegetables or fruits, cereals, bread, meat, cake and yogurt) and living conditions in a farm environment (presence and diversity of farm animals).

Health - Agronomy / Food Science - 17.12.2018
A diet rich in cheese in early childhood could protect against allergies
A diet rich in cheese in early childhood could protect against allergies
A study conducted by the University Hospital of Besançon and INRA shows the protective effect of high cheese consumption from a very young age. For the first time, a link has been established between cheese consumption and the probability of developing food or skin allergic diseases, regardless of the consumption of various other foods (vegetables or fruits, cereals, bread, meat, cake and yogurt) and living conditions in a farm environment (presence and diversity of farm animals).

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