Postdoctoral positions in Inflammation and Stromal Immunoregulation

Emploi

Équipe: Stroma, inflammation et réparation tissulaire

Département de: Immunologie

Département de: Biologie du développement et cellules souches

Membre : Lucie Peduto 15 Feb 2023

Our laboratory at Institut Pasteur (Paris) has two positions available for postdoctoral fellows in the area of inflammation and regenerative disease research. We are interested in mechanisms of tissue homeostasis, adaptation and repair, with [...]

Our laboratory at Institut Pasteur (Paris) has two positions available for postdoctoral fellows in the area of inflammation and regenerative disease research. We are interested in mechanisms of tissue homeostasis, adaptation and repair, with an emphasis on tissue long lived cells such as stromal cells. Using novel genetic and pharmacological tools, we investigate the stromal signaling and crosstalk with immune cells, stem cells and other resident cells in different physiological and pathological conditions with a focus on inflammatory and regenerative disorders. We perform mostly in vivo studies, combining lineage tracing and depletion models, flow cytometry, confocal microscopy and unbiased approaches such as single cells transcriptomics and epigenetics to characterize molecular and cellular mechanisms. Building on similar approaches, we offer two postdoc positions to investigate stromal regulation of inflammation and non-specific tissue memory in response to acute/chronic immune activation and environmental challenges. We are particularly interested on stroma-immune crosstalk and cellular plasticity in organs such as the adipose tissue and skeletal muscle.

Required qualifications: Successful applicants have a recent PhD or MD/PhD degree in immunology or related biomedical disciplines, with a track record of publications and lab experience in one or more areas that include: immunology, vascular biology, tissue repair, adipose tissue biology, skeletal muscle biology, matrix biology, mesenchymal stem cells. Highly motivated candidates interested in areas of research at the intersection of stromal/stem cell biology and immunology are strongly encouraged to apply. Specific requirements:

• Required: Previous experience with in vivo rodent models and flow cytometry
• Desirable: Experience with transcriptomics (RNAseq), mouse genetics or confocalimaging, previous experience in adipose tissue/ skeletal muscle biology
• Would be a plus: Experience or interest in big data analysis and scripting languages (R, Python)

The position is available starting from February 2023 for two years, renewable. Benefits include comprehensive family healthcare coverage and 6 weeks paid annual leave. Research will be conducted at Institut Pasteur in the center of Paris, which contains state of- the-art facilities and a highly collaborative research environment with 13 Departments across Biology/Physics/Biomedical fields. Our lab is co-affiliated with the Departments of "Immunology" and "Developmental and Stem Cell Biology", facilitating interactions and collaborations in these different research areas.

For more information and to apply, send a motivation letter, CV and contact information for 2 references to Lucie Peduto (lucie.pedutopasteur.fr).

Recent publication of the lab: PDGFR?-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms. Jacob et al., Cell Stem Cell, 29(5): 856-868, 2022.

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