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Scientist GPCR structural biology

Closing Date
WorkplaceVilligen, North West Switzerland, Switzerland
Job Start15.09.2021

The company

Founded in 2015, leadXpro AG is a lead compound discovery company focusing on membrane protein drug targets such as GPCRs, ion-channels and transporters for the discovery and optimization of next-generation medicines. Based on a unique platform for membrane protein expression, purification and engineering, the preferred access to synchrotron/free electron laser (SLS/SwissFEL) for X-ray analysis and cryo-EM facilities (Uni Basel), leadXpro is able to characterize the interaction of small molecules and biotherapeutics with drug targets timely to impact the drug discovery of novel therapeutics. The position at leadXpro is an excellent opportunity to join a young and exciting company engaged in cutting-edge applied research. leadXpro is located at PARK INNOVAARE, 5234 Villigen, Switzerland. For more information, please visit: ?url=http%3A%2F%2Fleadxpro.com&module=jobs&id=25821" target="_blank" rel="nofollow">http://leadxpro.com


The position

leadXpro is urgently seeking a highly motivated and enthusiastic X-ray crystallographer who will be part of an interdisciplinary team of scientists working on leadXpro proprietary and partnered projects, within a highly collaborative international environment. She/he will perform membrane protein purification and their biochemical characterization in quantities that enable structural and biophysical studies. She/he will carry out crystallization trials, crystals optimization, data collection at synchrotron and structural solution of GPCR/ligand complexes.

Key tasks and responsibilities

The successful candidate will be expected to work within a dynamic team that values transparency, integrity, reliability and a passion for science to create benefits for patients.

Key duties include:

  • GPCR construct design to enhance expression, stability and crystallisability
  • Purification of GPCR using standard chromatography methods
  • Constructs screening, monitoring of protein quality and purity using fluorescence-size exclusion chromatography
  • Crystallisation of GPCR in lipidic cubic phase, vapour diffusion or bicelle crystallisation
  • Data collection at synchrotron, data processing and structural refinement of GPCR/ligand complexes
  • Work in collaboration with a multi-discipline team and external collaborators
  • Actively develop the scientific reputation and methodology of GPCR crystallisation of the company


Key qualifications and requirements

The successful candidate should have

  • A Ph.D. in biochemistry, molecular biology, biotechnology or a related discipline
  • At least 5 years of postdoctoral experience in an academic or industrial setting
  • Demonstrated expertise and success track record in GPCR/membrane protein structural biology
  • Excellent track record of crystallisation and structural solution of GPCR/ligand complexes
  • In-depth knowledge of synchrotron data collection and X-ray crystallography data processing software packages including CCP4, XDS and PHENIX
  • Excellent interpersonal communication skills and fluency in English
  • Proven ability to work in a collaborative environment
  • Experience in an industrial environment will be an advantage

Contact and Address

How to apply

If you are interested to join the team, please send your complete application in English with the keyword “Scientist - GPCR structural biology” in the subject line to: infoleadXpro.com

The deadline for the application is May 15th, 2021.



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In your application, please refer to myScience.fr and reference JobID 25821.

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