Warning: this advert is not valid anymore. ()

Postdoctoral and PhD position – Pathogen-phagocyte inter-kingdom signaling

 
University of Zürich
Institute of Medical Microbiology

Published
Closing Date
WorkplaceZürich, Gloriastrasse 30, Zurich region, Switzerland
Category
Position
Duration2-4 Jahre
Occupation rate
100%
Job StartJuly 1st 2021, or per agreement

The University of Zürich is an academic research and teaching institution of international standing.

Description

The environmental bacterium Legionella pneumophila causes a severe pneumonia termed Legionnaires’ disease in humans and forms a unique replication-permissive vacuole in amoebae and macrophages. Pathogen-host cell interactions are governed by more than 300 different secreted bacterial "effector" proteins as well as by a small signaling molecule called LAI-1 (Legionella autoinducer-1). LAI-1 promotes inter-bacterial communication (quorum sensing) as well as prokaryote-eukaryote trans-kingdom signaling.
The project funded by the Swiss National Science Foundation aims at elucidating Legionella-phagocyte trans-kingdom signaling through LAI-1. To study the production, secretion, delivery, cellular targets and mode of action of LAI-1, the successful applicants will use a broad range of techniques in the disciplines Microbiology (handling of BL-2 pathogens, infection analysis, bacterial genetics), Cell Biology (confocal fluorescence microscopy, flow cytometry, RNA interference) and Biochemistry (FPLC/HPLC, protein-ligand interactions, purification of Legionella vacuoles).

Requirements

Highly motivated individuals with an interest and background in Microbiology, Cell Biology, Biochemistry or a related area are invited to apply.

We offer

The positions (up to 4 years) are available at the Institute of Medical Microbiology, University of Zürich main campus, as of July 1st 2021, or upon mutual agreement.

Contact and Address

Please send your CV with a motivation letter and the contact details of 2 references as a single pdf file to Prof. Dr. Hubert Hilbi (hilbiimm.uzh.ch). For further information please contact Hubert Hilbi and visit our website (https://www.imm.uzh.ch/de/research/experimental/Hilbi.html).

Email

Phone

044 634 2650

Web

Warning: this advert is not valid anymore. ()
In your application, please refer to myScience.fr and reference JobID 25946.

This site uses cookies and analysis tools to improve the usability of the site. More information. |