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Results 21 - 40 of 54.


Health - Pharmacology - 12.04.2022
HIV: The Antibodies of 'Post-treatment Controllers'
HIV: The Antibodies of ’Post-treatment Controllers’
A very small percentage of people with HIV-1, known as "post-treatment controllers” (PTCs), are able to control their infection after interrupting all antiretroviral therapy. Understanding the fundamental mechanisms that govern their immune response is essential in order to develop HIV-1 vaccines, novel therapeutic strategies to achieve remission, or both.

Life Sciences - Pharmacology - 11.04.2022
Epigenetic treatments: New allies for chemotherapies?
If genetics is interested in gene sequencing, epigenetics studies how genes are going to be used, or not used, by a cell. The epigenome of a cell represents the set of chemical modifications of the DNA or associated proteins that will determine the expression of the genes and thus the cell's identity.

Astronomy / Space Science - Earth Sciences - 01.04.2022
Perseverance records the first ever sounds from Mars
Perseverance records the first ever sounds from Mars
Using a microphone developed in France, the Perseverance rover has recorded the first ever sounds from Mars audible to the human ear. By analysing these sounds, scientists have been able to find out more about the physical characteristics of the Martian atmosphere, and in particular about the speed of sound and its attenuation there.

Health - Agronomy / Food Science - 24.03.2022
Artificial Sweeteners: Possible Link to Increased Cancer Risk
Artificial Sweeteners: Possible Link to Increased Cancer Risk
Artificial sweeteners are used to reduce the amounts of added sugar in foods and beverages, thereby maintaining sweetness without the extra calories. These products, such as diet sodas, yoghurts and sweetener tablets for drinks, are consumed by millions of people daily. However, the safety of these additives is the subject of debate.

Pharmacology - Health - 24.03.2022
Increased Ischemic Stroke Risk Associated with Certain Medications for Nausea and Vomiting
Every year in France, 140,000 people have a stroke 1 . Around 80% are ischemic strokes or cerebral infarctions, which occur when a brain artery is obstructed by a blood clot. Studies have shown that the risk of ischemic stroke is increased by the use of antipsychotics: medications with antidopaminergic 2 properties that are commonly prescribed in psychiatry.

Health - Pharmacology - 21.03.2022
COVID-19: 'Reactive' Vaccination, Effective in Case of High Viral Circulation?
COVID-19: ’Reactive’ Vaccination, Effective in Case of High Viral Circulation?
Although the majority of its population is fully vaccinated, the virus continues to actively circulate in France. As health restrictions are being lifted, fears of a resurgence of the epidemic and of the emergence of new more contagious variants are leading scientists to consider new strategies to continue to promote vaccination among populations that remain hesitant.

Life Sciences - Health - 16.03.2022
Discovery of an immune escape mechanism promoting Listeria infection of the central nervous system
Discovery of an immune escape mechanism promoting Listeria infection of the central nervous system
Some "hypervirulent" strains of Listeria monocytogenes have a greater capacity to infect the central nervous system. Scientists from the Institut Pasteur, Université Paris Cité, Inserm and the Paris Public Hospital Network (AP-HP) have discovered a mechanism that enables cells infected with Listeria monocytogenes to escape immune responses.

Health - Pharmacology - 14.03.2022
MICA: A New Immune Response Gene That Predicts Kidney Transplant Failure
MICA: A New Immune Response Gene That Predicts Kidney Transplant Failure
Although a kidney transplant is the only curative treatment for end-stage kidney disease, the risk of the patient's body rejecting the graft means that success is not guaranteed. To reduce this risk, physicians are now able to look at a certain number of genetic and immunological parameters in order to evaluate the histocompatibility between donor and recipient - i.e. how compatible their organs and tissues are.

Social Sciences - 07.03.2022
How do spiders hunt 'in unison'
How do spiders hunt ’in unison’
Within the 50,000 known species of spiders about 20 have developed a permanent social life characterised by a remarkable cooperation 1 . Among these, one or two species hunt "in packs", such as the Anelosimus eximius spiders of French Guyana, whose colonies can house several thousand individuals of all ages, coexisting peacefully in gigantic webs that often reach several cubic metres.

Health - Social Sciences - 01.03.2022
Significant Increase in Infant Mortality in France
The infant mortality rate (IMR) is a key indicator of population health. In the absence of updated data on the statistical trends of this indicator in France, researchers from Inserm, Université de Paris, the Paris public hospitals group (AP-HP) and Nantes University Hospital, in collaboration with teams from the University of California, analyzed civil registry data from the French National Institute of Statistics and Economic Studies (INSEE) from 2001 to 2019.

Health - Pharmacology - 28.02.2022
Covid-19 - Towards a vaccination strategy adapted to immunosuppressed patients
Covid-19 - Towards a vaccination strategy adapted to immunosuppressed patients
Publication of the CIRI in the journal Science Translational Medicine on February 1 st , 2022. Claude Bernard Lyon 1 University focus on February 24, 2022. Transplant recipients, who receive therapeutic immunosuppression to prevent graft rejection, are characterized by high coronavirus disease 2019 (COVID-19)-related mortality and defective response to vaccines.

Health - Pharmacology - 24.02.2022
Discovery of an innate immunological memory in the intestine
Discovery of an innate immunological memory in the intestine
The innate immune system plays a crucial role in regulating host-microbe interactions, and especially in providing protection against pathogens that invade the mucosa. Using an intestinal infection model, scientists from the Institut Pasteur and Inserm discovered that innate effector cells - group 3 innate lymphoid cells - act not only during the early stages of infection but can also be trained to develop an innate form of immunological memory that can protect the host during reinfection.

Health - Pharmacology - 24.02.2022
Better Understanding the Role of a White Blood Cell Type in SARS-CoV-2 Immune Response
Better Understanding the Role of a White Blood Cell Type in SARS-CoV-2 Immune Response
Although the response of various immune cells to SARS-CoV-2 infection has been relatively well studied, that of basophils (a category of white blood cells) had not been characterized yet - mainly because of their rarity in that they represent around 0.5% of the body's white blood cells. In a new study, researchers from Inserm, Sorbonne Université, Université de Paris, CNRS, Institut Pasteur and Efrei describe how basophils respond to SARS-CoV-2 infection.

Life Sciences - 23.02.2022
Wolbachia manipulates insect spermatozoa with a nuclear toxin
Publication of the LBMC in the journal Current biology on February 7, 2022. CNRS-INSB communication on February 21, 2022. Wolbachia are widespread endosymbiotic bacteria that manipulate the reproduction of arthropods through a diversity of cellular mechanisms. In cytoplasmic incompatibility (CI), a sterility syndrome originally discovered in the mosquito Culex pipiens , uninfected eggs fertilized by sperm from infected males are selectively killed during embryo development following the abortive segregation of paternal chromosomes in the zygote.

Life Sciences - Health - 21.02.2022
Transplantation chemotherapy eliminates regenerative capacity of brain's innate immune cells
Transplantation chemotherapy eliminates regenerative capacity of brain’s innate immune cells
Brain microglia (green) initiating expression of cell division marker (red), but unable divide due to co-expression of a senescence marker (blue), due to the chemotherapy treatment (busulfan). K. Sailor/ PM Lledo, Institut Pasteur. Annually over 50,000 bone marrow transplantations occur worldwide as a therapy for multiple cancerous and non-cancerous diseases.

Life Sciences - 21.02.2022
Rats can estimate their timing accuracy
Rats can estimate their timing accuracy
Thanks to their capacity for introspection, human beings are able to estimate the duration of their actions. When they perform a task - especially a time-based task - they can evaluate their performance and correct themselves in order to do better next time.

Paleontology - Life Sciences - 21.02.2022
Balkanatolia: the forgotten continent that sheds light on the evolution of mammals
Balkanatolia: the forgotten continent that sheds light on the evolution of mammals
A team of geologists and palaeontologists has discovered that, some 50 million years ago, there was a low-lying continent separating Europe from Asia that they have named Balkanatolia. Geographical changes 40 to 34 million years ago connected this continent to its two neighbours, paving the way for the replacement of European mammals by Asian mammals.

Health - Pharmacology - 17.02.2022
Defeating leukaemia cells by depriving them of energy
Defeating leukaemia cells by depriving them of energy
Selective activation of the AMPK enzyme would lead to the death of leukaemia cells (in purple in this image). Jérôme Tamburini / UNIGE High resolution pictures A Swiss-French team that includes scientists has discovered how to trigger apoptosis in leukaemia cells by disrupting their energy maintenance mechanism.

Astronomy / Space Science - 15.02.2022
Discovery of a third moon orbiting the asteroid (130) Elektra
Discovery of a third moon orbiting the asteroid (130) Elektra
Publication of the CRAL in the journal Astronomy & Astrophysics on Fabruary 8, 2022. CNRS-INSU communication on February 14, 2022. Context . Extreme adaptive optics systems, such as the Spectro-Polarimetric High-contrast Exoplanet REsearch facility (SPHERE), push forward the limits in high contrast and high resolution in direct imaging.

Health - Pharmacology - 11.02.2022
A Novel Immunotherapy Approach Redirects Epstein-Barr Antibodies toward Disease-Causing Cells
A Novel Immunotherapy Approach Redirects Epstein-Barr Antibodies toward Disease-Causing Cells
Monoclonal antibody therapy can be very effective in treating numerous illnesses, such as cancers, chronic inflammatory conditions, and infectious diseases. However, it is costly and uses molecules that are complicated to produce. Therefore, it is essential to identify new therapeutic alternatives so that as many patients as possible get the treatments they need.

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