Radiotherapy : repair proteins in search of the ring to protect DNA

To understand why some cancer cells resist radiotherapy, an international team of researchers has used crystallography to “photograph” the first moments of the molecular ballet that allows these cells to repair their DNA. The study involved teams from the CEA, CNRS, SOLEIL (French synchrotron facility), University of Paris-Sud, Gustave Roussy, Aix-Marseille University and University Paul Sabatier - Toulouse III 1 . It was published in Nature Structural & Molecular Biology on October, the 5th.

Notes:

1. Project leaders: Institute of Integrative Biology of the Cell (I2BC), CEA Paris-Saclay, CNRS, University Paris-Sud; Institute of Molecular and Cellular Pharmacology (IPMC), IPBS, CNRS, University Paul Sabatier - Toulouse III, certified team under Ligue Contre le Cancer.

Bibliography:

XLF and APLF bind to Ku80 on two remote sites to ensure repair by non-homologous end-joining. Clement Nemoz et. al., Nature Structural & Molecular Biology , 5 October 2018.

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