Healthy cells can impact tumour progression during embryonic development

Avian embryo model of neuroblastoma. Physiological signals from embryonic tissue

Avian embryo model of neuroblastoma. Physiological signals from embryonic tissues in which tumours develop cause some cells to acquire more aggressive traits, break away, and spread to remote sites, seeding metastases. © MeLiS_Equipe Castellani

Half of childhood cancers arise during the development of the human embryo, which greatly complicates research into these diseases. The team of Valérie Castellani, CNRS senior researcher at the Mechanisms in Integrated Life Sciences (MeLiS) laboratory (CNRS / INSERM / Claude Bernard Lyon 1 University) has thus developed a model that optimally simulates the human embryonic environment by grafting human cancer cells into a chick embryo. This new method, for which Castellani won’t , makes it possible to explore the mechanisms of metastasis, i.e. how cancer cells spread throughout the body, and to investigate the role of normal cells in the behaviour of malignant ones. Using the chick embryo model, Castellani’s team, in partnership with the Biology and Biotechnology for Health (BioSanté) laboratory  (CEA / INSERM / Université Grenoble Alpes) and the L yon Paediatric Haematology and Oncology Institute (Centre Léon Bérard / Hospices Civils de Lyon 1 ), trained their attention on neuro blastomas, paediatric cancers originating in neurons that have yet to mature. The metastatic forms of these cancers are extremely aggressive. Published (10 May 2022) and led by Dounia Ben Amar, a PhD candidate cosupervised by CNRS researcher Céline Delloye-Bourgeois, the study found that certain healthy, developing neurons promote metastatic behaviour in the neuroblastoma cells with which they come into contact.  It not only shows that normal cells can play a part in tumour progression during embryonic development,  but also illustrates the importance of better understanding the unique developmental environment within which cancers of embryonic origin form.

1 Oncofactory and the Institute of Biology of the École Normale Supérieure (CNRS / INSERM / ENS-PSL) were also involved in this study.


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