Some GnRH neurons (green) express NOS1 (red) during their migration from the nose to the brain during fetal life. GnRH + NOS1 double-labeled cells are shown in yellow. Vincent Prévot/Inserm
Some GnRH neurons ( green ) express NOS1 ( red ) during their migration from the nose to the brain during fetal life. GnRH + NOS1 double-labeled cells are shown in yellow. Vincent Prévot/Inserm - Children born prematurely have a higher risk of suffering from cognitive and sensory disorders but also infertility in adulthood. In a new study, a team of researchers from Inserm, the University Hospital of Lille and the University of Lille, within the Lille Neuroscience and Cognition Laboratory, raises interesting avenues to improve their prognosis. While working on a rare disease called congenital hypogonadotropic hypogonadism, the scientists discovered the key role of an enzyme and the therapeutic potential of the neurotransmitter it synthesizes - nitric oxide - to reduce the risk of long-term complications in cases of prematurity. The findings are described in Science Translational Medicine . The research team has also launched a clinical trial at the University Hospital of Lille in partnership with a hospital in Athens (Greece) to go further and measure the effect of nitric oxide in premature infants.
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