Under the watchful eye of scientists, viruses become the muses of therapeutic innovation.

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Illustration of the article
Illustration of the article
Work by a consortium of scientists, including a team from the Centre International de Recherche en Infectiologie (CIRI, CNRS/Inserm/ENS de Lyon/Université Lyon 1), describes viruses as modulators of human cell functions. The interaction interfaces of viral proteins with human proteins are used as matrices to design original chemical molecules, offering new perspectives in multiple therapeutic areas. Using this approach, scientists have identified a new molecule with promising activity against non-alcoholic fatty liver disease.

The study, published in PNAS, was the subject of a paper by CNRS Biology.

Reference

Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery .Laurène Meyniel-Schicklin, Jérôme Amaudrut, Pierre Mallinjoud, Fabrice Guillier, Philippe E. Mangeot, Laetitia Lines, Anne Aublin-Gex, Caroline Scholtes, Claire Punginelli, Stéphane Joly, Florence Vasseur, Evelyne Manet, Henri Gruffat, Thomas Henry, Farès Halitim, Jean-Laurent Paparin, Peter Machin, Raphaël Darteil, Diane Sampson, Ivan Mikaelian, Lydie Lane, Vincent Navratil, Marie-Pierre Golinelli-Cohen, Fabiola Terzi, Patrice André, Vincent Lotteau, Jacky Vonderscher, Eric C. Meldrum, and Benoit de Chassey. PNAS , January 22, 2024.

DOI: 10.1073/pnas.2308776121