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A new class of molecules capable of killing the cancer cells that are refractory to standard treatments and responsible for recurrence has just been developed by scientists at Institut Curie, the CNRS, and Inserm. This crucial advance in the fight against metastatic cancer is based on identifying the cellular site for ferroptosis initiation, a natural process, catalysed by iron, that sparks the oxidative degradation of cell membranes.

Characteristic depressive episodes are the most common mental disorders worldwide. One in five people will suffer from depression in their lifetime, with suicidal risk responsible for several thousand deaths a year in France.

Human fibroblasts observed by fluorescence microscopy. Mitochondria are marked in red, fibroblast core DNA is marked in blue © Nivea Dias Amoedo/Inserm A deterioration in skin quality, its ability to heal, and its normal aging, is often observed in people with chronic hyperglycemia. A team of researchers from Inserm, the University of Bordeaux and LVMH Recherche has investigated how hyperglycemia alters the human dermis, and in particular the cells involved in its healing, the fibroblasts.

While glioblastoma is a highly aggressive brain tumor that currently offers little hope of cure, researchers at the CANTHER laboratory (CNRS / Inserm / University of Lille / Lille University Hospital / Pasteur Institute of Lille) and the Laboratoire de Bioimagerie et Pathologies (CNRS / University of Strasbourg) have succeeded in identifying different forms of this tumor and mapping them precisely by analyzing the activity of gene regulatory factors.

Food additive mixtures are an everyday feature of our diets, especially through ultra-processed foods. Until recently, safety evaluations of these additives have been conducted substance by substance due to a lack of data on the effect of them ingested together. In a new study, researchers from Inserm, INRAE, Sorbonne Paris Nord University, Paris Cité University and Cnam, as part of the Nutritional Epidemiology Research Team (CRESS-EREN), examined the possible links between exposure to mixtures of commonly consumed food additives and the onset of type 2 diabetes.

Many cases of sudden cardiac death could be avoided thanks to artificial intelligence. As part of a new study to be published in European Heart Journal, a network of artificial neurons imitating the human brain was developed by researchers from Inserm, Paris Cité University and the Paris public hospitals group (AP-HP), in collaboration with their colleagues in the USA.

Mouse macrophages visualized using confocal microscopy, showing the nuclei (blue) and the actin network (orange). Mónica Fernández Monreal, Bordeaux Imaging Center Macrophages, key cells of the immune system, play a central role in cleaning the body by ingesting and destroying pathogens (bacteria, viruses, etc.) and damaged cells.

Motoneurones (stained by immunohistochemistry for ChAT) of the lumbar section of the spinal cord in ALS mouse models. Scale 100 mm © Simon J Guillot, Daniel Beckett ,Matei Bolborea Amyotrophic Lateral Sclerosis (ALS), Charcot's disease, or Lou Gehrig's disease is a severe neurodegenerative disease that leads to progressive paralysis of muscles involved in voluntary movement.

The Remember project provides new insights into post-traumatic stress disorder © Inserm Following a shocking, dangerous or frightening experience, such as a terrorist attack, many people develop post-traumatic stress disorder (PTSD). In order to improve its management, numerous scientific studies are examining the neurobiological processes underlying the development of this disorder.

Scientists from Toulouse's UMR IHAP (INRAE/ENVT) and the Netherlands' Wageningen Bioveterinary Research have developed a new tool for optimizing contact tracing in infected farms. This was published in the Journal Royal Society Interface on January 8, 2025 . Highly pathogenic avian influenza (HPAI) is a major threat to domestic poultry, causing considerable economic losses and requiring rapid intervention to limit its spread.

A study published in the international journal Emerging Infectious Diseases (EID) by Toulouse-based scientists from UMR IHAP (INRAE/ENVT) demonstrates that enhanced event-based surveillance, based on weekly sampling of ducks found dead, is the most effective strategy for rapidly detecting the presence of highly pathogenic avian influenza (HPAI) virus in duck farms vaccinated against HPAI.

MASH is a growing pandemic worldwide, with obesity and diabetes on the rise. It is also an area of significant unmet medical need. François Pattou Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease (NAFLD), impacts roughly 30% of the global adult population.

With the rise of antibiotics in the 1930s, phage therapy (i.e. the use of viruses called bacteriophages to fight bacterial infections) was abandoned. Today, with the rise of antibiotic resistance making the treatment of bacterial infections increasingly difficult, phage therapy is once again attracting the interest of doctors and researchers, despite the complexity of its application due to the great diversity and specificity of bacteriophages.

The higher we climb, the lower the oxygen supply to our bodies. Since 2019, a research team from Inserm, Grenoble Alpes University and Grenoble Alpes University Hospital has been investigating the health consequences of oxygen restriction. Their work has taken them to Peru, to Rinconada, the world's highest city (5,300 m), which has become a veritable open-air laboratory.

Unsplash Teams from the departments of clinical and biological hematology, obstetrics and gynecology, pharmacovigilance, medical intensive care, infectiology, as well as the clinical research unit of theHôpital Cochin-Port Royal AP-HP, Université Paris Cité, Inserm and the HEMAPREG network, coordinated by Mr Pierre Pinson and Drs Ismael Boussaid and Rudy Birsen, have conducted a study on pregnancy-associated hematological cancers.

Myotubular myopathy is a rare genetic disease caused by mutations in the MTM1 gene. A study carried out in animals by researchers from Inserm, CNRS and the University of Strasbourg at the IGBMC, in collaboration with American teams, has shed light on the underlying mechanisms of this disease. Published in the journal Science , these studies suggest that vitamin K supplementation could improve certain symptoms of the disease, opening up new therapeutic prospects.

Central Africa, especially the Democratic Republic of the Congo (DRC), is highly affected by successive mpox outbreaks. Until now, the extent of genetic diversity of the virus had not been well characterised in this region of the world. For the first time, as part of the AFROSCREEN project and the PANAFPOX project , teams from the Institut National de Recherche Biomédicale (INRB) in DRC, IRD and Inserm have provided important new information on the genetic diversity of mpox virus circulating in DRC and on the predominant route of transmission.

Researchers at INRAE have developed an artificial mouth to reproduce and better understand the processing of soft foods. The device is based on anatomical data collected at the Fujita Health University and features a silicone tongue that contracts using compressed air to mimic the movements of the human tongue.

Nirsevimab is an antibody targeting the respiratory syncytial virus (RSV). Available in France since September 2023, it is indicated in neonates and infants for the prevention of bronchiolitis caused by RSV. AdobeStock Nirsevimab is an antibody targeting the respiratory syncytial virus (RSV). Available in France since September 2023, it is indicated in neonates and infants for the prevention of bronchiolitis caused by RSV.

Listeria monocytogenes, a bacterium that causes listeriosis, a serious disease, can go into dormancy when confronted with environmental stress, for example in the presence of detergents or in water devoid of nutrients. It then becomes undetectable by the tests commonly used in the food industry and hospitals, thus representing a major health risk.