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Life Sciences - 10.04.2024
Under the watchful eye of scientists, viruses become the muses of therapeutic innovation.
Under the watchful eye of scientists, viruses become the muses of therapeutic innovation.
Work by a consortium of scientists, including a team from the Centre International de Recherche en Infectiologie (CIRI, CNRS/Inserm/ENS de Lyon/Université Lyon 1), describes viruses as modulators of human cell functions. The interaction interfaces of viral proteins with human proteins are used as matrices to design original chemical molecules, offering new perspectives in multiple therapeutic areas.

Life Sciences - 09.04.2024
Surprising role of female sex pheromone in crop pest: new biocontrol possibilities?
INRAE researchers have discovered that female pheromones play a remarkable role in the African cotton moth. In general, these pheromones trigger mate attraction, promoting encounters between males and females during reproductive periods. Astonishingly, the African cotton moth possesses a pheromonal compound whose modulatory effects exceed those of light itself, a discovery that can inform future biocontrol strategies.

Life Sciences - Health - 14.03.2024
Amyotrophic lateral sclerosis: a new avenue for improving patient diagnosis and follow-up
Amyotrophic lateral sclerosis: a new avenue for improving patient diagnosis and follow-up
Amyotrophic lateral sclerosis or Charcot's disease is a neurodegenerative disease that results in progressive paralysis and subsequent death. Diagnosing it is difficult and no curative treatment exists to date, making these challenges for research. In a new study, Inserm researcher Caroline Rouaux and her team at the Strasbourg Biomedical Research Centre (Inserm-Université de Strasbourg), in collaboration with researchers from Ludwig Maximilian University in Munich, CNRS and Sorbonne Université, show that electroencephalography could become a diagnostic and prognostic tool for the disease.

Life Sciences - Music - 06.03.2024
The brain mechanisms behind our desire to dance
Why does some music make us want to dance more than others? This is the question that a research team from Inserm and Aix-Marseille Université tried to answer by studying the desire to dance (also called the 'groove') and the brain activity of 30 participants who were asked to listen to music. Their findings show that the groove sensation is highest for a moderately complex rhythm and that the desire to move is reflected in the brain by an anticipation of the music's rhythm.

Life Sciences - Environment - 29.02.2024
Unveiling rare diversity: the origin of heritable mutations in trees
What is the origin of genetic diversity in plants? Can new mutations acquired during growth be passed on to seeds? INRAE scientists, in collaboration with CIRAD and the CNRS, have used the French Guiana forest as the setting for their research, leading to a series of discoveries on this fundamental question in biology.

Health - Life Sciences - 29.02.2024
COVID-19: A potential treatment for loss of smell
One of the most persistent and debilitating symptoms of COVID19 is anosmia or loss of smell. Researchers at INRAE and ENVA have discovered that a corticoid treatment could help restore the olfactory capacities affected by the viral infection. These results, published on XX February in Brain, Behavior, and Immunity, are a major step forward in understanding and treating this symptom.

Health - Life Sciences - 26.02.2024
New discovery on iron metabolism improves anemia treatment
Anemia is a major public health problem worldwide, affecting around a third of the population. There are many causes of anemia, but the most common are a defect in the production of red blood cells, a lack of iron in the blood or genetic diseases such as thalassemia. A better understanding of iron metabolism is essential to improve management of the many patients affected.

Health - Life Sciences - 26.02.2024
Improving the treatment of anaemia thanks to a new discovery in iron metabolism
An essential component of the haemoglobin in red blood cells, iron is crucial to many biological processes - including the transport and storage of oxygen in the body. © Inserm/Claude Féo Anaemia is a major public health problem worldwide, affecting around one third of the population. Its causes are multiple, but the most common are a lack of red blood cell production, a lack of iron in the blood, and genetic diseases such as thalassaemia.

Life Sciences - 21.02.2024
Food additive E551 could promote coeliac disease
A recent study has found that food additive E551, also known as silicon dioxide, can reduce oral tolerance to dietary proteins and could foster the development of coeliac disease. Born of a collaboration among researchers at INRAE and McMaster University in Canada, this pioneering work is the first to highlight the potential toxicity of E551, a nanometric ingredient that is added to a wide range of consumer food products.

Health - Life Sciences - 20.02.2024
Obesity: opt for omega 3 fatty acids to prevent the associated risks
In yellow, microglia (immune cells of the brain) activated by the pro-inflammatory nature of a sunflower oil-enriched diet (fluorescence microscopy). Clara Sanchez/Inserm Obesity is a major public health problem, affecting around 650 million adults worldwide , and is often associated with systemic and cerebral inflammation as well as anxiety and cognitive disorders, such as memory deficits.

Health - Life Sciences - 19.02.2024
New cell senescence discoveries open up therapeutic avenues in fighting age-related diseases
An increase in glycerol kinase (GK) enzyme activity on its own is capable of halting cell proliferation and initiating a programme of senescence. The blue staining of the cells is a biomarker of senescence. This image shows cells overexpressing the GK enzyme. Khaled Tighanimine/team Mario Pende. Cell senescence is a physiological process that has been associated in many studies with age-related diseases.

Life Sciences - 08.02.2024
Back to the future: not all grape varieties succumbed to the extreme heat wave of 2019
Heat waves are increasingly common worldwide, making it necessary to adapt our crops. A new study by INRAE and Institut Agro, based on an experiment conducted during an unprecedented heatwave in France in June 2019, has uncovered regions of grapevine genome associated with extreme heat tolerance. The results were published on 7 February in New Phytologist.

Agronomy / Food Science - Life Sciences - 07.02.2024
Back to the future: 2019’s extreme heatwave didn’t kill all grape varieties
As heatwaves intensify in France, we need to adapt our crops. A new study by INRAE and Institut Agro reveals the genome regions involved in tolerance to extreme temperatures in grapevines - thanks to an experiment using the exceptional canicular episode of June 2019. Results published on February 7 in New Phytologist.

Health - Life Sciences - 16.01.2024
HIV: early treatment, one key to remission
HIV: early treatment, one key to remission
People living with HIV need to take antiretroviral treatment for life to prevent the virus from multiplying in their body. But some people, known as "post-treatment controllers,- have been able to discontinue their treatment while maintaining an undetectable viral load for several years. Starting treatment early could promote long-term control of the virus if treatment is discontinued.

Life Sciences - 04.01.2024
Ancestors of primates lived in pairs
Ancestors of primates lived in pairs
A study carried out by CNRS 1  scientists working with an international team has revealed that around 70 million years ago, when dinosaurs existed, the ancestors of primates most commonly lived in pairs. Only 15% of them opted for a solitary lifestyle. This discovery - that our ancestors adopted variable forms of social organization - challenges the hitherto commonly accepted hypothesis that at the time of dinosaurs, the ancestors of primates lived alone, and that pair living evolved much later.

Life Sciences - 20.12.2023
Wildflowers increasingly doing without insect pollinators
Wildflowers increasingly doing without insect pollinators
Scientists at the CNRS and the University of Montpellier 1 have discovered that flowering plants growing in farmland are increasingly doing without insect pollinators. As reproduction becomes more difficult for them in an environment depleted in pollinating insects, the plants are evolving towards self-fertilisation.

Life Sciences - Health - 18.12.2023
Set of bacterial genes essential for colonising plant roots
Like humans and animals, plants have a microbiota that shapes their health and thanks to which they assimilate nutrients from the soil. How is this microbiota assembled? Using an innovative approach, scientists at the Max Planck Institute and INRAE have discovered three genes essential for bacteria to colonise plants and live in and on plant roots.

Life Sciences - Health - 11.12.2023
Discovery of the role of a brain regulator involved in psychiatric illnesses
Contrary to all expectations, GluD1 - a receptor considered to be excitatory - has been shown in the brain to play a major role in controlling neuron inhibition. Given that alterations in the GluD1 gene are encountered in a certain number of neurodevelopmental and psychiatric disorders, such as autism (ASD) and schizophrenia, this discovery opens up new therapeutic avenues to combat the imbalances between excitatory and inhibitory neurotransmissions associated with these disorders.

Life Sciences - Health - 08.12.2023
The very first 3D map of the embryonic human head enables new insights into its development
The very first 3D map of the embryonic human head enables new insights into its development
3D light-sheet microscope image of a lacrimal gland of a tissue-cleared 12-week-old human embryo. The different elements of the gland were coloured using virtual reality software.

Health - Life Sciences - 08.12.2023
First 3D mapping in the embryo
First 3D mapping in the embryo
Improving our knowledge of the development of the complex structures that make up the human head, and thus gaining a better understanding of the congenital anomalies that cause malformations: this is the challenge that a team of researchers from Inserm, CNRS and Sorbonne Université at the Institut de la vision, Université Claude Bernard Lyon 1 and Hospices civils de Lyon is well on the way to meeting.
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