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Health - Life Sciences - 19.09.2023 
Infection of Certain Neurons With SARS-CoV-2 Could Cause Persistent Symptoms
The brain impacts of infection with SARS-CoV-2, responsible for COVID-19, are increasingly well documented in the scientific literature. Researchers from Inserm, Lille University Hospital and Université de Lille, at the Lille Neuroscience & Cognition unit, in collaboration with their colleagues at Imperial College London, focused more specifically on the impacts of this infection on a population of neurons known for regulating sexual reproduction via the hypothalamus (the neurons that express the GnRH hormone).
Health - Life Sciences - 19.09.2023
Health - Life Sciences - 18.09.2023 
First identification of the causes of a rare facial malformation
The Translational Medicine and Targeted Therapies research team, headed by Prof. Guillaume Canaud at the Institut Necker-Enfants Malades (Université Paris Cité, AP-HP, Inserm), in collaboration with the maxillofacial surgery team from theHôpital Necker-Enfants Malades AP-HP (Prof. Roman Khonsari and Prof. Arnaud Picard) and the "Shape and Growth of the Skull" laboratory (Prof. Roman Khonsari), studied the PIK3CA pathway in patients suffering from a rare disease affecting facial muscles, hemifacial myohyperplasia.
Pharmacology - Life Sciences - 28.08.2023 
A major step forward in the treatment of narcolepsy
Difficulty staying awake may seem trivial, but it's the main symptom of one of the most severe sleep disorders: narcolepsy. In Montpellier, the Centre de référence des narcolepsies et hypersomnies rares (Inserm/University/CHU de Montpellier) headed by Yves Dauvilliers is conducting cutting-edge research into this disease.
Life Sciences - 28.08.2023
Life Sciences - 21.08.2023
Physics - Life Sciences - 17.07.2023
Life Sciences - 12.07.2023
Life Sciences - Health - 27.06.2023 
Neurodevelopmental disorders in children: a new gene implicated
Faced with childhood neurodevelopmental disorders, how to break the therapeutic deadlock - The answer may well lie in the genes of the proteasome, an intracellular machinery responsible for eliminating defective proteins from the cell. A research team from Inserm, CNRS, Nantes University and Nantes University Hospital, working at the Institut du Thorax and in collaboration with international teams, has studied the genomes of 23 children with neurodevelopmental disorders.
Life Sciences - Health - 27.06.2023 
Neurodevelopmental Disorders in Children: A New Gene Called Into Question
In the face of childhood neurodevelopmental disorders, how can we get out of the therapeutic "dead end”' The answer could well be found in the genes of the proteasome - an intracellular mechanism that is responsible for removing defective proteins from the cell. A research team from Inserm, CNRS, Nantes Université and Nantes University Hospital, at the Thorax Institute and in collaboration with international teams, studied the genome of 23 children with neurodevelopmental disorders.
Health - Life Sciences - 20.06.2023 
How Blood Stem Cells Detect Pathogens and Guide Immune Response
Correct immune system function depends on the continuous supply of white blood cells derived from stem cells that reside in the bone marrow. These are known as blood stem cells or hematopoietic stem cells. Researchers from Inserm, CNRS and Université d'Aix-Marseille at the Center of Immunology Marseille-Luminy have now discovered a new role played by these cells in immune response.
Health - Life Sciences - 20.06.2023 
How blood stem cells detect a pathogen and direct the immune response
The proper functioning of the immune system depends on a constant supply of white blood cells from the stem cells that reside in the bone marrow: blood stem cells - or hematopoietic stem cells. Researchers from Inserm, CNRS and the University of Aix-Marseille, at the Marseille-Luminy Immunology Center, have now discovered a new role played by these blood stem cells in the immune response.
Life Sciences - Health - 31.05.2023 
A Major Advance in the Genetics and Risk Factors of a Form of Infarction That Mainly Affects Women
Spontaneous coronary artery dissection, more commonly known under the acronym SCAD, is a cause of infarction of which 9 out of 10 of its victims are women in their forties in apparent good health. Still poorly understood, it is often underdiagnosed, which complicates treatment despite the fact that it could represent up to one third of infarction cases in women under 60 years of age.
Life Sciences - Health - 22.05.2023 
Liver cells control our biological clock
The liver could influence the body's central biological clock, a group of brain cells that influence most aspects of physiology and behaviour. Our liver plays a role in regulating our central biological clock, scientists from CNRS and Université Paris have discovered. The results of their study, published on 17 May in Science Advances, show that the biological clock of mice can be reprogrammed by inserting human liver cells into the animal's liver.
Life Sciences - Health - 22.05.2023 
Liver cells control our biological clock
The liver may influence the body's central biological clock, a group of brain cells that influence most physiological and behavioral aspects. Our liver partly controls our central biological clock, according to scientists from CNRS and Université Paris Cité. Their study, to be published on May 17, 2023 in the journal Science Advances, has indeed shown that it was possible to shift the biological clock of mice by introducing human liver cells into their liver.
Health - Life Sciences - 17.05.2023
Health - Life Sciences - 16.05.2023 
Eating Broccoli to Limit Skin Allergies
The severity of skin allergies can vary depending on many environmental factors, including diet. However, the role of specific nutrients had not been well documented until now. In a new study, researchers from Inserm and Institut Curie at the Immunity and Cancer unit have shown that the absence in the diet of compounds found in certain vegetables, particularly broccoli and cabbage, could worsen skin allergies in animal models.
Life Sciences - Health - 10.05.2023
Health - Life Sciences - 03.05.2023
Life Sciences - Environment - 19.04.2023 
New viruses related to both giant viruses and herpesviruses
A team from the CEA and CNRS have discovered the existence of mirusviruses: a major group of viruses abundant on the surface of the seas and oceans, where they infect single-celled plankton. These findings appear in Nature on 19 April. The discovery provides a better understanding of the scope of ocean biodiversity and the importance of viruses in these ecosystems.
Life Sciences
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The brain impacts of infection with SARS-CoV-2, responsible for COVID-19, are increasingly well documented in the scientific literature. Researchers from Inserm, Lille University Hospital and Université de Lille, at the Lille Neuroscience & Cognition unit, in collaboration with their colleagues at Imperial College London, focused more specifically on the impacts of this infection on a population of neurons known for regulating sexual reproduction via the hypothalamus (the neurons that express the GnRH hormone).
Towards better management of chronic renal failure
Researchers at Toulouse University Hospital, Inserm and Toulouse III - Paul Sabatier University have recently made a breakthrough in the understanding and treatment of chronic kidney disease, a pathology affecting millions of people worldwide. Published in Science Translational Medicine, this promising scientific breakthrough is based on the identification of the responsibility of an inflammatory protein in the serious complications of the disease, paving the way for a new therapeutic approach.
Researchers at Toulouse University Hospital, Inserm and Toulouse III - Paul Sabatier University have recently made a breakthrough in the understanding and treatment of chronic kidney disease, a pathology affecting millions of people worldwide. Published in Science Translational Medicine, this promising scientific breakthrough is based on the identification of the responsibility of an inflammatory protein in the serious complications of the disease, paving the way for a new therapeutic approach.
The Translational Medicine and Targeted Therapies research team, headed by Prof. Guillaume Canaud at the Institut Necker-Enfants Malades (Université Paris Cité, AP-HP, Inserm), in collaboration with the maxillofacial surgery team from theHôpital Necker-Enfants Malades AP-HP (Prof. Roman Khonsari and Prof. Arnaud Picard) and the "Shape and Growth of the Skull" laboratory (Prof. Roman Khonsari), studied the PIK3CA pathway in patients suffering from a rare disease affecting facial muscles, hemifacial myohyperplasia.
Difficulty staying awake may seem trivial, but it's the main symptom of one of the most severe sleep disorders: narcolepsy. In Montpellier, the Centre de référence des narcolepsies et hypersomnies rares (Inserm/University/CHU de Montpellier) headed by Yves Dauvilliers is conducting cutting-edge research into this disease.
A unique lipid signature guides cytokinesis in plant cells
Publication of the RDP in the journal Science Advances, on July 19, 2023. Communication of CNRS-INSB on August 28, 2023. Cytokinesis in multicellular organisms dictates how cells are organized in a tissue, their identities and functions. A study conducted by the Plant Reproduction and Development Laboratory (RDP - CNRS/ENS de Lyon/Inrae) and published in Science Advances , presents a quantitative analysis of cytokinesis steps in the model plant Arabidopsis using high-resolution microscopy approaches.
Publication of the RDP in the journal Science Advances, on July 19, 2023. Communication of CNRS-INSB on August 28, 2023. Cytokinesis in multicellular organisms dictates how cells are organized in a tissue, their identities and functions. A study conducted by the Plant Reproduction and Development Laboratory (RDP - CNRS/ENS de Lyon/Inrae) and published in Science Advances , presents a quantitative analysis of cytokinesis steps in the model plant Arabidopsis using high-resolution microscopy approaches.
Cascading genomic rearrangements induced by toxic DNA repair intermediates
Publication of the LBMC in the journal Genes and Development, on August 4, 2023. Communication of CNRS-INSB on August 21, 2023. DNA breaks disrupt the integrity of the chromosome and the genetic information it contains. In an article published in the journal Genes and Development , scientists from the Laboratory of Biology and Modelling of the Cell (LBMC - CNRS/ENS de Lyon), in collaboration with teams from the USA, have further characterized a mechanism that puts genome stability at risk.
Publication of the LBMC in the journal Genes and Development, on August 4, 2023. Communication of CNRS-INSB on August 21, 2023. DNA breaks disrupt the integrity of the chromosome and the genetic information it contains. In an article published in the journal Genes and Development , scientists from the Laboratory of Biology and Modelling of the Cell (LBMC - CNRS/ENS de Lyon), in collaboration with teams from the USA, have further characterized a mechanism that puts genome stability at risk.
How do you fit a bale of straw into the eye of a needle?
Publication of the Physics Laboratory in the journal PNAS, on July 18, 2022, and Nano Letters, on May 22, 2023. Communication of CNRS-INP on July 17, 2023. Researchers at the Physics laboratory of ENS de Lyon (CNRS/ENS de Lyon) have recreated artificial pores that mimic the functioning of two types of biological pore, paving the way for the manufacture of selective nano-pumps and nano-filters.
Publication of the Physics Laboratory in the journal PNAS, on July 18, 2022, and Nano Letters, on May 22, 2023. Communication of CNRS-INP on July 17, 2023. Researchers at the Physics laboratory of ENS de Lyon (CNRS/ENS de Lyon) have recreated artificial pores that mimic the functioning of two types of biological pore, paving the way for the manufacture of selective nano-pumps and nano-filters.
When cells listen to their microbiota
Publication of the IGFL in the journal eLife on June 9, 2023. Communication on Jully 12, 2023. In nature, it's all a matter of perception: it's by knowing their environment that living beings can react to it. Our cells, for example, are able to perceive the presence of bacteria on contact. But how? Using the fruit fly - Drosophila melanogaster - as a model, a research team led by the Institute of Functional Genomics of Lyon (IGFL, CNRS/ENS de Lyon) has described a new mechanism by which intestinal cells can "sense" and adapt to the bacteria in the microbiota.
Publication of the IGFL in the journal eLife on June 9, 2023. Communication on Jully 12, 2023. In nature, it's all a matter of perception: it's by knowing their environment that living beings can react to it. Our cells, for example, are able to perceive the presence of bacteria on contact. But how? Using the fruit fly - Drosophila melanogaster - as a model, a research team led by the Institute of Functional Genomics of Lyon (IGFL, CNRS/ENS de Lyon) has described a new mechanism by which intestinal cells can "sense" and adapt to the bacteria in the microbiota.
Faced with childhood neurodevelopmental disorders, how to break the therapeutic deadlock - The answer may well lie in the genes of the proteasome, an intracellular machinery responsible for eliminating defective proteins from the cell. A research team from Inserm, CNRS, Nantes University and Nantes University Hospital, working at the Institut du Thorax and in collaboration with international teams, has studied the genomes of 23 children with neurodevelopmental disorders.
In the face of childhood neurodevelopmental disorders, how can we get out of the therapeutic "dead end”' The answer could well be found in the genes of the proteasome - an intracellular mechanism that is responsible for removing defective proteins from the cell. A research team from Inserm, CNRS, Nantes Université and Nantes University Hospital, at the Thorax Institute and in collaboration with international teams, studied the genome of 23 children with neurodevelopmental disorders.
Correct immune system function depends on the continuous supply of white blood cells derived from stem cells that reside in the bone marrow. These are known as blood stem cells or hematopoietic stem cells. Researchers from Inserm, CNRS and Université d'Aix-Marseille at the Center of Immunology Marseille-Luminy have now discovered a new role played by these cells in immune response.
The proper functioning of the immune system depends on a constant supply of white blood cells from the stem cells that reside in the bone marrow: blood stem cells - or hematopoietic stem cells. Researchers from Inserm, CNRS and the University of Aix-Marseille, at the Marseille-Luminy Immunology Center, have now discovered a new role played by these blood stem cells in the immune response.
Spontaneous coronary artery dissection, more commonly known under the acronym SCAD, is a cause of infarction of which 9 out of 10 of its victims are women in their forties in apparent good health. Still poorly understood, it is often underdiagnosed, which complicates treatment despite the fact that it could represent up to one third of infarction cases in women under 60 years of age.
The liver could influence the body's central biological clock, a group of brain cells that influence most aspects of physiology and behaviour. Our liver plays a role in regulating our central biological clock, scientists from CNRS and Université Paris have discovered. The results of their study, published on 17 May in Science Advances, show that the biological clock of mice can be reprogrammed by inserting human liver cells into the animal's liver.
The liver may influence the body's central biological clock, a group of brain cells that influence most physiological and behavioral aspects. Our liver partly controls our central biological clock, according to scientists from CNRS and Université Paris Cité. Their study, to be published on May 17, 2023 in the journal Science Advances, has indeed shown that it was possible to shift the biological clock of mice by introducing human liver cells into their liver.
Women and Parkinson’s Disease: Physical Activity Found to Be Beneficial More Than Twenty Years Before Diagnosis
Although physical activity is regularly discussed as being one of the avenues for preventing Parkinson's disease (PD), studies so far had been unable to eliminate certain biases or had not focused on its specific role in women. Researchers from Inserm, Université Paris-Saclay and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) with the Gustave Roussy Institute studied the impact of physical activity on the development of PD in nearly 100,000 women from the French cohort E3N followed up over 29 years.
Although physical activity is regularly discussed as being one of the avenues for preventing Parkinson's disease (PD), studies so far had been unable to eliminate certain biases or had not focused on its specific role in women. Researchers from Inserm, Université Paris-Saclay and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) with the Gustave Roussy Institute studied the impact of physical activity on the development of PD in nearly 100,000 women from the French cohort E3N followed up over 29 years.
The severity of skin allergies can vary depending on many environmental factors, including diet. However, the role of specific nutrients had not been well documented until now. In a new study, researchers from Inserm and Institut Curie at the Immunity and Cancer unit have shown that the absence in the diet of compounds found in certain vegetables, particularly broccoli and cabbage, could worsen skin allergies in animal models.
Seeing with Sound
Restoring sight to blind people thanks to a therapy that combines genetics and ultrasound is the hope of Serge Picaud's team, director of the Vision Institute *, and the Physics for Medicine Laboratory of the ESPCI ** in partnership with the Institute of Molecular and Clinical Ophthalmology of Basel.
Restoring sight to blind people thanks to a therapy that combines genetics and ultrasound is the hope of Serge Picaud's team, director of the Vision Institute *, and the Physics for Medicine Laboratory of the ESPCI ** in partnership with the Institute of Molecular and Clinical Ophthalmology of Basel.
Long COVID: The Persistence of SARS-CoV-2 in the Mucous Membranes May Be A Factor
This transmission electron microscope image shows SARS-CoV-2, isolated from a patient in the U.S., emerging from the surface of cells cultivated in a laboratory. National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH. Public domain. Several months after infection with SARS-CoV-2, some patients still have symptoms: a phenomenon commonly referred to as "long COVID”.
This transmission electron microscope image shows SARS-CoV-2, isolated from a patient in the U.S., emerging from the surface of cells cultivated in a laboratory. National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH. Public domain. Several months after infection with SARS-CoV-2, some patients still have symptoms: a phenomenon commonly referred to as "long COVID”.
A team from the CEA and CNRS have discovered the existence of mirusviruses: a major group of viruses abundant on the surface of the seas and oceans, where they infect single-celled plankton. These findings appear in Nature on 19 April. The discovery provides a better understanding of the scope of ocean biodiversity and the importance of viruses in these ecosystems.
