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Pharmacology - 28.10.2021
Health - Pharmacology - 21.10.2021 
New, promising opportunities for treating skin fibrosis
Skin fibrosis impairs skin tissue function, and has a strong aesthetic impact. French researchers have now shown that applying an electric field to the skin could cure skin fibrosis by reducing overly high collagen levels. Collagen, the main component of the skin's extracellular matrix, can cause a pathological condition if it is in excess.
Health - Pharmacology - 20.10.2021 
A new therapeutic target to combat addiction?
Drug addiction is a psychiatric disorder for which no pharmacological treatment with long-term efficacy currently exists. All addictive substances share the property of raising concentrations of the neurotransmitter dopamine within brain regions forming the neural reward circuit. This increase in dopamine levels results in long-lasting alteration of signal transmission that is dependent on another neurotransmitter, glutamate, which causes addictive behaviours.
Health - Pharmacology - 01.12.2020 
Deciphering the energetic code of cells for better anticancer therapies
A procedure that may help personalise anticancer therapies has just been developed by the CNRS, INSERM, and Aix-Marseille University scientists at the Centre d'Immunologie de Marseille-Luminy, in association with colleagues from the University of California San Francisco and the Marseille Public University Hospital System (AP-HM), with support from Canceropôle Provence-Alpes-Côte d'Azur.
Health - Pharmacology - 04.05.2020
Pharmacology - 25.11.2019
Pharmacology - Life Sciences - 21.11.2019
Life Sciences - Pharmacology - 18.07.2019 
New prebiotics: benefits without the downsides?
Prebiotics are currently a preferred treatment for certain metabolic disorders, as they can restore the balance of dysfunctional gut microbiota, and improve the body's metabolism. However, these substances have to be used at high doses, which can result in patients experiencing bloating and flatulence.
Pharmacology - Health - 10.07.2019
Innovation - Pharmacology - 22.05.2019 
MaaT Pharma expands patent portfolio with three granted patents covering its microbiome restoration biotherapeutic platform
First patents to cover the fundamental processes for accessing the human gut microbiome as biotherapeutics. MaaT Pharma's microbiome sample collection and administration devices receive CE mark for use in collecting and administrating gut-derived samples as biotherapeutics to patients.
Pharmacology - Innovation - 27.02.2019 
CEA-Leti Breakthrough Opens Path To New Vaccine for HIV using Lipid-Nanoparticle-Delivery Technology
Lipidots Platform Strengthens Immune Response to Protein That Is Key to HIV Vaccine; Results Presented in Nature Publishing Group's npj Vaccines GRENOBLE, France - Feb. 27, 2019 - Leti, a research institute of CEA Tech, in collaboration with CEA's Fundamental Research Division , has developed a new vaccine approach for HIV based on engineered lipid nanoparticles that deliver p24 - a viral protein that is key to an HIV vaccine- and optimize the CpG adjuvant's effect.
Life Sciences - Pharmacology - 21.12.2018 
A novel antibiotic resistance mechanism
Bacteria make use of a number of natural resistance strategies to overcome antibiotics. And it seems that this bacterial toolbox may be much more varied than previously thought. Scientists at the Institut Pasteur, in collaboration with Inserm, INRA, the CNRS and the Weizmann Institute of Science in Israel, have recently revealed an entirely unknown resistance mechanism in Listeria monocytogenes bacteria.
Pharmacology
Results 1 - 12 of 12.
Chatbot for addressing COVID-19 vaccine hesitancy
A considerable fraction of the population is reluctant to get vaccinated against COVID-19. French scientists have designed a chatbot that offers personalised responses to questions posed by the curious or hesitant-and have demonstrated its effectiveness. What if a few minutes of interaction with a chatbot could effectively address vaccine concerns? In an article published in the Journal of Experimental Psychology: Applied (28 October 2021), researchers from the CNRS, INSERM, and ENS-PSL show that such an interface is indeed capable of swaying the vaccine-hesitant.
A considerable fraction of the population is reluctant to get vaccinated against COVID-19. French scientists have designed a chatbot that offers personalised responses to questions posed by the curious or hesitant-and have demonstrated its effectiveness. What if a few minutes of interaction with a chatbot could effectively address vaccine concerns? In an article published in the Journal of Experimental Psychology: Applied (28 October 2021), researchers from the CNRS, INSERM, and ENS-PSL show that such an interface is indeed capable of swaying the vaccine-hesitant.
Skin fibrosis impairs skin tissue function, and has a strong aesthetic impact. French researchers have now shown that applying an electric field to the skin could cure skin fibrosis by reducing overly high collagen levels. Collagen, the main component of the skin's extracellular matrix, can cause a pathological condition if it is in excess.
Drug addiction is a psychiatric disorder for which no pharmacological treatment with long-term efficacy currently exists. All addictive substances share the property of raising concentrations of the neurotransmitter dopamine within brain regions forming the neural reward circuit. This increase in dopamine levels results in long-lasting alteration of signal transmission that is dependent on another neurotransmitter, glutamate, which causes addictive behaviours.
A procedure that may help personalise anticancer therapies has just been developed by the CNRS, INSERM, and Aix-Marseille University scientists at the Centre d'Immunologie de Marseille-Luminy, in association with colleagues from the University of California San Francisco and the Marseille Public University Hospital System (AP-HM), with support from Canceropôle Provence-Alpes-Côte d'Azur.
Six new research projects concerning Covid-19
On April 10, 2020, ANR announced the funding of 86 projects concerning Covid-19. Six are associated with ENS de Lyon laboratories. The SARS-CoV-2 infection is a global emergency for human health. The interferon response is the body's first barrier to defending viral infections. This host response is initiated by the recognition of viral elements by receptor and leads to the production of molecules, including interferon, that alert surrounding cells.
On April 10, 2020, ANR announced the funding of 86 projects concerning Covid-19. Six are associated with ENS de Lyon laboratories. The SARS-CoV-2 infection is a global emergency for human health. The interferon response is the body's first barrier to defending viral infections. This host response is initiated by the recognition of viral elements by receptor and leads to the production of molecules, including interferon, that alert surrounding cells.
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
Publication by CIRI on November 25, 2019. Dogma in transplantation holds that microvascular inflammation (MVI) triggered by recipient's antibody response against alloantigens (antibody-mediated rejection) is the main cause of graft failure. Analysis of a cohort of 129 renal recipients with MVI on graft biopsy shows that, in half of the cases, histological lesions are not mediated by antibodies.
Publication by CIRI on November 25, 2019. Dogma in transplantation holds that microvascular inflammation (MVI) triggered by recipient's antibody response against alloantigens (antibody-mediated rejection) is the main cause of graft failure. Analysis of a cohort of 129 renal recipients with MVI on graft biopsy shows that, in half of the cases, histological lesions are not mediated by antibodies.
Get randomly lost, get home sooner
In a multicellular organism, gene expression regulation allows cells to live, divide and ensure their proper physiological role. The molecular nature of this process (e.g. low molecule number, Brownian movements...) involves random variations. Indeed, with the same genetic background, two neighbor cells do not express their genes in the same way.
In a multicellular organism, gene expression regulation allows cells to live, divide and ensure their proper physiological role. The molecular nature of this process (e.g. low molecule number, Brownian movements...) involves random variations. Indeed, with the same genetic background, two neighbor cells do not express their genes in the same way.
Prebiotics are currently a preferred treatment for certain metabolic disorders, as they can restore the balance of dysfunctional gut microbiota, and improve the body's metabolism. However, these substances have to be used at high doses, which can result in patients experiencing bloating and flatulence.
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in Familial Mediterranean Fever patients
Familial Mediterranean fever (FMF) is the most frequent hereditary systemic autoinflammatory syndrome. FMF is usually caused by bi-allelic mutations in the MEFV gene, encoding Pyrin. Conclusive genetic evidence lacks for about 30% of patients diagnosed with clinical FMF. Pyrin is an inflammasome sensor maintained inactive by two kinases (PKN1/2).
Familial Mediterranean fever (FMF) is the most frequent hereditary systemic autoinflammatory syndrome. FMF is usually caused by bi-allelic mutations in the MEFV gene, encoding Pyrin. Conclusive genetic evidence lacks for about 30% of patients diagnosed with clinical FMF. Pyrin is an inflammasome sensor maintained inactive by two kinases (PKN1/2).
First patents to cover the fundamental processes for accessing the human gut microbiome as biotherapeutics. MaaT Pharma's microbiome sample collection and administration devices receive CE mark for use in collecting and administrating gut-derived samples as biotherapeutics to patients.
Lipidots Platform Strengthens Immune Response to Protein That Is Key to HIV Vaccine; Results Presented in Nature Publishing Group's npj Vaccines GRENOBLE, France - Feb. 27, 2019 - Leti, a research institute of CEA Tech, in collaboration with CEA's Fundamental Research Division , has developed a new vaccine approach for HIV based on engineered lipid nanoparticles that deliver p24 - a viral protein that is key to an HIV vaccine- and optimize the CpG adjuvant's effect.
Bacteria make use of a number of natural resistance strategies to overcome antibiotics. And it seems that this bacterial toolbox may be much more varied than previously thought. Scientists at the Institut Pasteur, in collaboration with Inserm, INRA, the CNRS and the Weizmann Institute of Science in Israel, have recently revealed an entirely unknown resistance mechanism in Listeria monocytogenes bacteria.
