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Listeria monocytogenes, a bacterium that causes listeriosis, a serious disease, can go into dormancy when confronted with environmental stress, for example in the presence of detergents or in water devoid of nutrients. It then becomes undetectable by the tests commonly used in the food industry and hospitals, thus representing a major health risk.

In a study published in the journal Cell on 19 September, an international research team led by scientists from CNRS 1 , the University of Arizona and Scripps Research in California has identified animal species likely to have served as intermediate hosts for SARS-CoV-2, the virus responsible for the COVID-19 pandemic.

L'alimentation serait responsable d'environ 30% des décès dus aux maladies cardiovasculaires. Cardiovascular diseases are the leading cause of mortality in Western Europe, accounting for 1/3 of deaths in 2019. Diet is thought to be responsible for around 30% of such deaths. Nutrition-related prevention policies therefore constitute a major public health challenge for these diseases.

Epidemics of Ebola virus disease occur periodically in several sub-Saharan African countries. Two vaccines have already received WHO prequalification against the Ebolavirus Zaire species. However, information on the long-term immune response to these vaccines is still insufficient. We need to consolidate our knowledge on this subject to continue developing the safest and most effective vaccination strategies possible, for both adults and children.

Age-related macular degeneration (AMD) is the leading cause of visual disability in people over 50 years of age. Age-related macular degeneration (AMD) is the leading cause of visual disability in people over 50 years of age. Improving the treatment offering for patients is a major challenge for research.

Nearly one in three cancers develops following chronic inflammation, whose origin remains unclear. In a new study, researchers from Inserm, CNRS, Université Claude-Bernard Lyon 1 and the Léon Bérard Centre at the Cancer Research Center of Lyon identified lymphocytes involved in the inflammatory processes and that are thought to be implicated in the generation of these cancers.

The ANRS DOXYVAC trial, promoted and funded by ANRS Emerging Infectious Diseases, and conducted by research teams from Inserm, AP-HP, Université Paris Cité and Sorbonne Université (France), shows that a rapid rollout of smallpox vaccination with MVA-BN ( Modified vaccine Ankara ) among HIV-positive men who have sex with men significantly reduces the risk of mpox by 99%.

Acute myeloid leukaemia is one of the deadliest cancers. Leukaemic stem cells responsible for the disease are highly resistant to treatment. A team from the University of Geneva (UNIGE), University Hospital of Geneva (HUG), and Inserm has made a breakthrough by identifying some of the genetic and energetic characteristics of these stem cells.

Phospho-ERK (red), Green Fluorescent Protein (cyan) and DAPI coimmunofluorescence on spleen sections from mice carrying a KRAS G12C endothelial mutation © Guillaume Canaud The teams of the translational medicine and targeted therapies unit of the Necker-Enfants Malades AP-HP hospital, Inserm, Paris Cité University within the Necker-Enfants Malades Institute, coordinated by professors Guillaume Canaud (Université Paris Cité, AP-HP) and Laurent Gu

Jannis Brandt Unsplash The intestinal immune system is an indispensable intermediary in the complex association between diet and metabolism: without it, the dietary fibers present in fruit and vegetables cannot play a proper part in regulating blood sugar levels in the body. Researchers at Inserm and Sorbonne University have now demonstrated that a certain type of immune cell is essential for the beneficial effect of dietary fibre on carbohydrate metabolism.

When confronted with an antibiotic, toxic substance, or other source of considerable stress, bacteria are able to activate a defence mechanism using cell-to-cell communication to 'warn' unaffected bacteria, which can then anticipate, shield themselves and spread the warning signal. This mechanism 1 has just been described for the first time by a team of scientists 2 from CNRS and Université de Toulouse III - Paul Sabatier.

MRI image showing the reconstructed pulmonary valve (circled in red) that is closing perfectly 7 days after implantation. Fabien Kawecki/Inserm Researchers from Inserm have developed a pulmonary valve using human collagen. A device that could ultimately be a game-changer in the treatment of paediatric heart diseases, such as tetralogy of Fallot.

In France, 900 000 people have Alzheimer's disease or a related condition. The risk of developing Alzheimer's depends on genetic and environmental factors. Among these factors, various epidemiological studies suggest that the regular consumption of moderate amounts of caffeine slows age-related cognitive decline and the risk of developing the disease.

In France, 900,000 people suffer from Alzheimer's or a related disease. The risk of developing Alzheimer's disease depends on genetic and environmental factors. Among the latter, various epidemiological studies suggest that regular, moderate caffeine consumption slows age-related cognitive decline and the risk of developing Alzheimer's disease.

Ageing greatly increases the risk of ischaemic stroke. A team of researchers from Inserm, Caen-Normandy University Hospital and Université de Caen Normandie have looked at the role that immune cells known as central nervous system-associated macrophages (CAMs) could play in the neurological damage that occurs following a stroke.

The teams from the kidney transplantation department of Necker-Enfants Malades AP-HP hospital, Inserm and Paris Cité University, as part of the Paris Translational Research Center for Organ Transplantation (PARCC), coordinated by doctor Olivier Aubert and Professor Alexandre Loupy conducted a study on the benefit of liquid biopsy (cfDNA) as a technique for predicting kidney transplant rejection.

A research team 1 led by scientists from CNRS and Université Grenoble Alpes has discovered that the injection of a modified "pseudo-prion" protein into the brains of mice could protect the animals against Alzheimer's disease, a pathology that currently affects nearly a million people in France. This neurodegenerative disease originates from lesions caused by an abnormal accumulation in the brain of two proteins: amyloid- and Tau.

By studying the brain anatomy of newborn baby baboons, a research group including several CNRS scientists 1 was able to predict what hand they would use to communicate after they had been weaned. These researchers had already found that nearly 70% of newborn baboons, like human babies, had early asymmetry in the planum temporale (PT) area of the brain.

The fungus Magnaporthe oryzae ravages rice and wheat crops and poses a formidable threat to human food on a global scale. Researchers from INRAE, CIRAD and the Université de Montpellier, together with the Hunan Hybrid Rice Research Centre (HHRRC) and the International Rice Research Institute (IRRI) have discovered a gene in rice for resistance to this pathogen, challenging the findings of a study that remained the reference for 25 years.

Numerous cellular phenomena are guided by mechanical forces, such as embryonic development or the spread of metastases. These phenomena are the subject of intense research aimed at understanding how they are translated into biological processes. Particular emphasis is being placed on new opportunities to treat diseases as resistant as cancer or fibrosis.