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Health - Life Sciences - 22.05.2017
Men/Women: not all equal in the face of allergic asthma
Researchers led by Jean-Charles Guéry of the Centre for Pathophysiology Toulouse Purpan (Inserm/Université Toulouse III - Paul Sabatier/ CNRS) are providing new insights into the possible link between male hormones and differences in gender in susceptibility to allergic asthma. This study demonstrates that hormones such as testosterone act on the immune system.

Health - Life Sciences - 19.05.2017
Vitamin D, a New Avenue in the Prevention of Alzheimer‘s Disease’
Known to be a possible cause of several chronic diseases, vitamin D'deficiency is also suspected to lead to a high risk of developing Alzheimer's disease, especially where the diet is also poor in 'good fats' and antioxidant carotenoids. This is what two studies led by Catherine Féart and Cécilia Samieri, researchers at Inserm unit 1219 Bordeaux Population Health (BPH) (Inserm/ Bordeaux University), have shown.

Life Sciences - Health - 10.05.2017
Human intestinal microbiota: progress towards a standardised protocol for the processing of stool samples
Human intestinal microbiota: progress towards a standardised protocol for the processing of stool samples
Obtaining extensive knowledge about human intestinal microbiota and assessing its impact on health requires a standardisation of the metagenomic* methods used. As part of a vast international project, researchers from INRA and the CEA 1 have revealed the major impact of DNA extraction on the evaluation of the microbial composition of human stool samples.

Agronomy / Food Science - Health - 09.05.2017
Organic pollutants and obesity are not a good combination
A team of researchers from Prof. Robert Barouki's Inserm unit (Inserm Unit 1124/Université Paris Descartes), led by Prof. Xavier Coumoul, has recently shown that the Seveso dioxin, an organic pollutant found in our food and in the atmosphere, causes liver damage in mice fed a high-fat diet.

Health - Life Sciences - 02.05.2017
Two blood tests for predicting the efficacy of a lung cancer treatment
ALK gene rearrangement is observed in 4% of non-small-cell lung cancer (NSCLC) patients. Researchers from Gustave Roussy, Inserm and Université Paris-Sud, have shown that two blood samples can now predict the efficacy of treatment (crizotinib). These blood samples (taken before treatment initiation and 2 months afterwards) are able to measure the changes in the number of circulating tumor cells (CTC) with a specific genetic abnormality (abnormal number of ALK gene copies).

Health - 02.05.2017
When liquids turn to solids: the mystery of corn starch elucidated
When liquids turn to solids: the mystery of corn starch elucidated
Some particle suspensions, such as grains of starch in water that are liquid at rest, suddenly solidify when they are subjected to vigorous shearing or impact. This fascinating behavior, called shear thickening, can make it possible to "walk on water" or design lightweight and supple jackets that are nevertheless highly shock-resistant.

Health - 27.04.2017
The composition of gut microbiota can predict the efficacy and tolerance of immunotherapy in people with cancer
Teams from AP-HP, INRA, Gustave Roussy and Inserm can demonstrate the role of microbiota in the response of immunotherapy for cancer. They show that in man, the composition of gut microbiota can help to identify the patients who will respond favourably or not to treatment for melanoma, with Ipilimumab.

Health - Administration - 06.04.2017
Ebola: New trial launched in West Africa to evaluate three vaccination strategies
The French National Institute of Health and Medical Research (Inserm), the US National Institutes of Health (NIH) and the London School of Hygiene & Tropical Medicine (LSHTM), in collaboration wi

Health - Life Sciences - 05.04.2017
New step towards the treatment of myotubular myopathy
A team of researchers in France, led by Dr. Ana Buj-Bello (Genethon/Inserm) and teams at the University of Washington and Harvard Medical School in the United States, achieved a new step towards the treatment of myotubular myopathy by gene therapy. The researchers demonstrated the efficacy of administration of a therapeutic vector by a single intravenous injection and identified the dose that restores long-term muscular strength in a large animal model of the disease.

Health - Physics - 30.03.2017
Mini X-ray sensor for high-precision medical applications
Mini X-ray sensor for high-precision medical applications
The ability to detect X-rays on a tiny scale paves the way for high-precision medical imaging and therapies. Such detection capabilities have been achieved by researchers from the CNRS, the University of Franche-Comté (UFC), and Aix-Marseille University (AMU), who attached an X-ray sensor to the end of an optical fiber.

Health - Career - 23.03.2017
Stimunity Signs an Exclusive License Agreement with Institut Curie and Inserm
Paris, March 21st, 2017 - Stimunity, Institut Curie and Inserm are pleased to announce that the company has signed an exclusive worldwide license agreement on two key patents that cover Stimunity's core technology VLP-cGAMP to develop new drugs in immuno-oncology. All started with a fundamental discovery made by the laboratory Innate Immunity at Institut Curie, leads by Dr. Nicolas Manel, Senior Researcher at Inserm and co-founder of Stimunity.

Life Sciences - Health - 23.03.2017
Microbiota and food contaminants: a mycotoxin amplifies the genotoxic effects of intestinal bacteria
Microbiota and food contaminants: a mycotoxin amplifies the genotoxic effects of intestinal bacteria
Using animal models, INRA researchers and their collaborators 1 have been studying the interactions between the bacterial microbiota and a common food contaminant: the mycotoxin deoxynivalenol (DON). They found that the presence of DON enhances the genotoxic effects of certain bacteria. More specifically, it increases the damage caused to the DNA of intestinal cells, contributing to the appearance of cancerous cells.

Life Sciences - Health - 23.03.2017
The human embryo as you have never seen it
A team coordinated by Alain Chédotal, Inserm research director at the Institut de la Vision (Inserm/UPMC/CNRS) and Paolo Giacobini at the Jean Pierre Aubert research centre (Inserm/Lille University) have just made a series of new observations of the anatomy of human embryos from 6 to 14 weeks old. A feat made possible by combining two recent techniques in immunomarking and 3D microscopy and a technique making the tissues transparent.

Health - Agronomy / Food Science - 17.03.2017
Effects of the gut microbiota revisited
Matteo Serino, Inserm Research Fellow at the Digestive Health Research Institute (IRSD, an Inserm/University of Toulouse III - Paul Sabatier/National Veterinary College of Toulouse/Inra joint research unit), and his collaborators show that alteration of the intestinal microbiota, whether nutritional or genetic in origin, may have beneficial effects on liver metabolism.

Health - Life Sciences - 15.03.2017
Discovery of an HIV reservoir marker: A new avenue toward eliminating the virus
Discovery of an HIV reservoir marker: A new avenue toward eliminating the virus
French researchers have identified a marker that makes it possible to differentiate “dormant” HIV-infected cells from healthy cells. This discovery will make it possible to isolate and analyze reservoir cells which, by silently hosting the virus, are responsible for its persistence even among patients receiving antiviral treatment, whose viral load is undetectable.

Health - Life Sciences - 15.03.2017
Discovery of an HIV reservoir marker: A new avenue toward eliminating the virus
French researchers have identified a marker that makes it possible to differentiate 'dormant' HIV-infected cells from healthy cells. This discovery will make it possible to isolate and analyze reservoir cells which, by silently hosting the virus, are responsible for its persistence even among patients receiving antiviral treatment, whose viral load is undetectable.

Life Sciences - Health - 14.03.2017
Toward the synthesis of antibiotics by a new bacterial enzyme
Researchers at the French National Institute for Agricultural Research (Inra) and Inserm have discovered a new family of bacterial enzymes that can produce hitherto unidentified peptides with antibiotic activity. Published , this work holds promise for the synthesis of molecules of pharmaceutical interest and the design of new antibiotics.

Health - 10.03.2017
A warning on taking ibuprofen during pregnancy
A new study conducted by Inserm researchers at Irset (Institute of Research in Environmental and Occupational Health) shows that ibuprofen is liable to cause disruptions in the hormone system in the human foetal testis, with possible implications for the development of the male urogenital tract. This drug suppresses the production of various testicular hormones, including testosterone, which controls the primary and secondary sex characteristics and the descent of the testes.

Life Sciences - Health - 08.03.2017
Lack of sleep causes brain impairment in adolescents
Not sleeping enough or going to bed too late leads to a reduction in the volume of grey matter in the brains of adolescents. These conclusions were obtained by researchers at Inserm Unit 1000, 'Neuroimaging and Psychiatry' (Inserm/Paris-Descartes University/Paris Sud University), who studied the brain and sleep habits of 177 14-year-old students.

Life Sciences - Health - 02.03.2017
Breast cancer: identification of a molecular switch that controls cancer stem cells
Some cancer cells are resistant to treatment and persist. If they are capable of proliferating again, even a very small number of these cells may be enough to reconstitute a tumour after or despite treatment. Various approaches to eliminate these 'cancer stem cells' (CSCs) have been tried in recent years: targeted therapies, vaccination and tumour starvation.
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