Microbubbles are used every day as contrast agents in medical sonography, and are the subject of intense research for the delivery of therapeutic agents. There are a number of options available to manipulate these microbubbles, including the use of light and sound, although the potential of the latter remains largely unexplored. In their research 1 published on 22 June 2020 in PNAS, CNRS researcher Diego Baresch and Valeria Garbin 2 , a researcher at the Delft University of Technology (The Netherlands), show that it is entirely possible to manipulate microbubbles through the use of "acoustical tweezers," a tool developed in 2016 that uses an acoustical beam to trap an object without contact. In using these acoustical tweezers through layers of bio-mimicking and elastic materials, they successfully surpassed the limitations of optical tweezers, 3 which cannot propagate through opaque media (such as in vivo tissue). As a result, the scientists have opened the way for a broader application of acoustical tweezers in biology and biomedicine, for instance for the highly-localized, reproducible, and controlled delivery of medicine, or for in vitro tissue engineering using stem cells.