Smoking cessation : a genetic mutation involved in relapse

Why is it so difficult to stop smoking? Why do some people relapse months after giving up? Scientists from the Institut Pasteur and the CNRS, in collaboration with Sorbonne University and Inserm, have demonstrated that a genetic mutation already known to be involved in sensitivity to nicotine also plays a role in relapse behavior after cessation in rats. The findings were published in the journal Current Biology on October 4, 2018.


A human polymorphism in CHRNA5 is linked to relapse to nicotine seeking in transgenic rats. Benoit Forget, Petra Scholze, Francina Langa, Carole Morel, Stephanie Pons, Sarah Mondoloni, Morgane Besson, Romain Durand-de Cuttoli, Audrey Hay, Ludovic Tricoire, Bertrand Lambolez, Alexandre Mourot, Philippe Faure and Uwe Maskos. Current Biology , 4 october 2018.

  • 8 October 2018
    2018 Nobel Prize in Physics : Statement about ELI project video
  • 5 October 2018
    A French-South Korean International Joint Unit inaugurated in Seoul
  • October 4, 2018
    Thirteen ocean solutions for climate change
  • 3 October 2018
    Scientific misconduct : the CNRS announces penalties against two senior researchers
  • 3 October 2018
    Smoking cessation : a genetic mutation involved in relapse
  • 2 October 2018
    Gérard Mourou wins the 2018 Nobel Prize in Physics
  • 1st October 2018
    A research project in the French West Indies for repurposing Sargassum seaweed
  • 1 October 2018
    A first : cross-country study looks at social integration among minority adolescents

This site uses cookies and analysis tools to improve the usability of the site. More information. |