Smoking cessation : a genetic mutation involved in relapse

Why is it so difficult to stop smoking? Why do some people relapse months after giving up? Scientists from the Institut Pasteur and the CNRS, in collaboration with Sorbonne University and Inserm, have demonstrated that a genetic mutation already known to be involved in sensitivity to nicotine also plays a role in relapse behavior after cessation in rats. The findings were published in the journal Current Biology on October 4, 2018.

Bibliography:

A human polymorphism in CHRNA5 is linked to relapse to nicotine seeking in transgenic rats. Benoit Forget, Petra Scholze, Francina Langa, Carole Morel, Stephanie Pons, Sarah Mondoloni, Morgane Besson, Romain Durand-de Cuttoli, Audrey Hay, Ludovic Tricoire, Bertrand Lambolez, Alexandre Mourot, Philippe Faure and Uwe Maskos. Current Biology , 4 october 2018.

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