Career - May 24
Aix-Marseille University and all the partners of the A*Midex consortium celebrate 10 years of the Initiative of Excellence
Aix-Marseille University and all the partners of the A*Midex consortium celebrate 10 years of the Initiative of Excellence
Innovation - May 6
Launch of 3ALP, a public-private laboratory dedicated to the aluminium of the future
Launch of 3ALP, a public-private laboratory dedicated to the aluminium of the future
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Life Sciences - Health - 25.05.2022 
Women-specific mechanisms may contribute to tumor progression
Researchers have demonstrated the role of a non-coding RNA in the development of aggressive tumors, particularly in breast cancer. The study, conducted in collaboration between the Institut Curie, Inserm, CNRS, Institut Paoli Calmettes and Aix-Marseille University , has just been published in the journal Cell .
Health - Life Sciences - 17.05.2022 
Phage Therapy: A Model to Predict Its Efficacy against Pathogenic Bacteria
Antibiotic resistance represents a major public health challenge, associated with a high mortality rate. While bacteriophages - viruses that kill bacteria - could be a solution for fighting antibiotic-resistant pathogens, various obstacles stand in the way of their clinical development.
Life Sciences - Health - 10.05.2022 
Healthy cells can impact tumour progression during embryonic development
Half of childhood cancers arise during the development of the human embryo, which greatly complicates research into these diseases. The team of Valérie Castellani, CNRS senior researcher at the Mechanisms in Integrated Life Sciences (MeLiS) laboratory (CNRS / INSERM / Claude Bernard Lyon 1 University) has thus developed a model that optimally simulates the human embryonic environment by grafting human cancer cells into a chick embryo.
Life Sciences - Social Sciences - 02.05.2022 
A link between social network size and brain structure?
The more social relationships we have, the more certain structures in our brain are developed. This has been the hypothesis of various neuroscience research projects for several years. With previous findings having highlighted the role of our social environment as one of the key factors behind the expansion of the cerebral cortex, researchers from Inserm and Université Lyon Claude Bernard Lyon 1, in collaboration with the University of Pennsylvania, went one step further in elucidating this link.
Life Sciences - 21.04.2022 
Dynamic finite-element simulations reveal early origin of complex human birth pattern
An interdisciplinary and international research team realized the first 4-dimensional simulation of hominin birth, constituting an important methodological advance for paleo-obstetrics. The researchers found that australopithecines gave birth to relatively small brained newborns, implying that they were helpless at birth similar to modern humans and their mothers thus needed the help of group members.
Life Sciences - Health - 15.04.2022 
Decoding a direct dialog between the gut microbiota and the brain
Gut microbiota by-products circulate in the bloodstream, regulating host physiological processes including immunity, metabolism and brain functions. Scientists from the Institut Pasteur (a partner research organization of Université Paris Cité), Inserm and the CNRS have discovered that hypothalamic neurons in an animal model directly detect variations in bacterial activity and adapt appetite and body temperature accordingly.
Health - Life Sciences - 14.04.2022
Life Sciences - Pharmacology - 11.04.2022
Life Sciences - Health - 16.03.2022 
Discovery of an immune escape mechanism promoting Listeria infection of the central nervous system
Some "hypervirulent" strains of Listeria monocytogenes have a greater capacity to infect the central nervous system. Scientists from the Institut Pasteur, Université Paris Cité, Inserm and the Paris Public Hospital Network (AP-HP) have discovered a mechanism that enables cells infected with Listeria monocytogenes to escape immune responses.
Life Sciences - 23.02.2022
Life Sciences - Health - 21.02.2022 
Transplantation chemotherapy eliminates regenerative capacity of brain’s innate immune cells
Brain microglia (green) initiating expression of cell division marker (red), but unable divide due to co-expression of a senescence marker (blue), due to the chemotherapy treatment (busulfan). K. Sailor/ PM Lledo, Institut Pasteur. Annually over 50,000 bone marrow transplantations occur worldwide as a therapy for multiple cancerous and non-cancerous diseases.
Life Sciences - 21.02.2022 
Rats can estimate their timing accuracy
Thanks to their capacity for introspection, human beings are able to estimate the duration of their actions. When they perform a task - especially a time-based task - they can evaluate their performance and correct themselves in order to do better next time.
Paleontology - Life Sciences - 21.02.2022 
Balkanatolia: the forgotten continent that sheds light on the evolution of mammals
A team of geologists and palaeontologists has discovered that, some 50 million years ago, there was a low-lying continent separating Europe from Asia that they have named Balkanatolia. Geographical changes 40 to 34 million years ago connected this continent to its two neighbours, paving the way for the replacement of European mammals by Asian mammals.
Health - Life Sciences - 25.01.2022
Life Sciences - Psychology - 20.01.2022 
New Brain Abnormalities Associated with Child Abuse
In collaboration with a Canadian team, scientists from Inserm and Université de Tours, at Unit 1253 Imaging & Brain1, have shown in post-mortem brain samples that victims of child abuse present specific brain characteristics. The teams have revealed for the first time in humans an increase in the number and maturation of perineuronal nets, dense protein structures surrounding the neurons.
Health - Life Sciences - 11.01.2022 
Identification of a novel therapeutic target in Multiple Myeloma
Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 years post-diagnosis. Proteasome inhibitors, the therapeutic backbone of current treatments, are very effective in treating newly diagnosed cancers but resistance or intolerance to these molecules inevitably develop, leading to relapses.
Life Sciences - 13.12.2021 
Experiment gives rise to social conventions between baboons
Shaking hands is an example of a social convention to say hello or goodbye. For the first time, scientists have studied the development of social conventions in non-human primates. Baboons, for example, can also establish conventions A research team from the CNRS and Aix-Marseille Université has demonstrated that members of a group of baboons can establish shared social conventions - in this case, by all agreeing on how to solve a problem in order to get a reward faster.
Life Sciences - 01.12.2021 
When variations in Earth’s orbit drive biological evolution
Coccolithophores are microscopic algae that form tiny limestone plates, called coccoliths, around their single cells. The shape and size of coccoliths varies according to the species. After their death, coccolithophores sink to the bottom of the ocean and their coccoliths accumulate in sediments, which faithfully record the detailed evolution of these organisms over geological time.
Life Sciences - History / Archeology - 20.10.2021 
Origin of domestic horses finally established
The modern horse was domesticated around 2200 years BCE in the northern Caucasus. In the centuries that followed it spread throughout Asia and Europe. To achieve this result, an international team of 162 scientists collected, sequenced and compared 273 genomes from ancient horses scattered across Eurasia.
Health - Life Sciences - 21.09.2021 
Breast cancers: ruptures in cell nuclei promotes tumor invasion
Cell nuclei protect the DNA. Nuclei can rupture when cells are deformed, causing DNA damage. In the case of breast cancer, this damage makes tumour cells more invasive, with increased risk of metastasis. When cells multiply and migrate, they can be compressed and their nucleus may break open. This phenomenon causes DNA damage.
Life Sciences
Results 1 - 20 of 265.
Researchers have demonstrated the role of a non-coding RNA in the development of aggressive tumors, particularly in breast cancer. The study, conducted in collaboration between the Institut Curie, Inserm, CNRS, Institut Paoli Calmettes and Aix-Marseille University , has just been published in the journal Cell .
Antibiotic resistance represents a major public health challenge, associated with a high mortality rate. While bacteriophages - viruses that kill bacteria - could be a solution for fighting antibiotic-resistant pathogens, various obstacles stand in the way of their clinical development.
Half of childhood cancers arise during the development of the human embryo, which greatly complicates research into these diseases. The team of Valérie Castellani, CNRS senior researcher at the Mechanisms in Integrated Life Sciences (MeLiS) laboratory (CNRS / INSERM / Claude Bernard Lyon 1 University) has thus developed a model that optimally simulates the human embryonic environment by grafting human cancer cells into a chick embryo.
The more social relationships we have, the more certain structures in our brain are developed. This has been the hypothesis of various neuroscience research projects for several years. With previous findings having highlighted the role of our social environment as one of the key factors behind the expansion of the cerebral cortex, researchers from Inserm and Université Lyon Claude Bernard Lyon 1, in collaboration with the University of Pennsylvania, went one step further in elucidating this link.
An interdisciplinary and international research team realized the first 4-dimensional simulation of hominin birth, constituting an important methodological advance for paleo-obstetrics. The researchers found that australopithecines gave birth to relatively small brained newborns, implying that they were helpless at birth similar to modern humans and their mothers thus needed the help of group members.
Gut microbiota by-products circulate in the bloodstream, regulating host physiological processes including immunity, metabolism and brain functions. Scientists from the Institut Pasteur (a partner research organization of Université Paris Cité), Inserm and the CNRS have discovered that hypothalamic neurons in an animal model directly detect variations in bacterial activity and adapt appetite and body temperature accordingly.
Colon cancer: how mutation of the APC gene disrupts lymphocyte migration
Migrating human T lymphocytes revealing a broad protrusion at the leading edge and long adhesive protrusions at the rear. Image obtained by confocal fluorescence microscopy: filamentous actin, pink; VLA4 adhesion protein, blue. Institut Pasteur/Lymphocyte Cell Biology. Image by Marta Mastrogiovanni In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity.
Migrating human T lymphocytes revealing a broad protrusion at the leading edge and long adhesive protrusions at the rear. Image obtained by confocal fluorescence microscopy: filamentous actin, pink; VLA4 adhesion protein, blue. Institut Pasteur/Lymphocyte Cell Biology. Image by Marta Mastrogiovanni In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity.
Epigenetic treatments: New allies for chemotherapies?
If genetics is interested in gene sequencing, epigenetics studies how genes are going to be used, or not used, by a cell. The epigenome of a cell represents the set of chemical modifications of the DNA or associated proteins that will determine the expression of the genes and thus the cell's identity.
If genetics is interested in gene sequencing, epigenetics studies how genes are going to be used, or not used, by a cell. The epigenome of a cell represents the set of chemical modifications of the DNA or associated proteins that will determine the expression of the genes and thus the cell's identity.
Some "hypervirulent" strains of Listeria monocytogenes have a greater capacity to infect the central nervous system. Scientists from the Institut Pasteur, Université Paris Cité, Inserm and the Paris Public Hospital Network (AP-HP) have discovered a mechanism that enables cells infected with Listeria monocytogenes to escape immune responses.
Wolbachia manipulates insect spermatozoa with a nuclear toxin
Publication of the LBMC in the journal Current biology on February 7, 2022. CNRS-INSB communication on February 21, 2022. Wolbachia are widespread endosymbiotic bacteria that manipulate the reproduction of arthropods through a diversity of cellular mechanisms. In cytoplasmic incompatibility (CI), a sterility syndrome originally discovered in the mosquito Culex pipiens , uninfected eggs fertilized by sperm from infected males are selectively killed during embryo development following the abortive segregation of paternal chromosomes in the zygote.
Publication of the LBMC in the journal Current biology on February 7, 2022. CNRS-INSB communication on February 21, 2022. Wolbachia are widespread endosymbiotic bacteria that manipulate the reproduction of arthropods through a diversity of cellular mechanisms. In cytoplasmic incompatibility (CI), a sterility syndrome originally discovered in the mosquito Culex pipiens , uninfected eggs fertilized by sperm from infected males are selectively killed during embryo development following the abortive segregation of paternal chromosomes in the zygote.
Brain microglia (green) initiating expression of cell division marker (red), but unable divide due to co-expression of a senescence marker (blue), due to the chemotherapy treatment (busulfan). K. Sailor/ PM Lledo, Institut Pasteur. Annually over 50,000 bone marrow transplantations occur worldwide as a therapy for multiple cancerous and non-cancerous diseases.
Thanks to their capacity for introspection, human beings are able to estimate the duration of their actions. When they perform a task - especially a time-based task - they can evaluate their performance and correct themselves in order to do better next time.
A team of geologists and palaeontologists has discovered that, some 50 million years ago, there was a low-lying continent separating Europe from Asia that they have named Balkanatolia. Geographical changes 40 to 34 million years ago connected this continent to its two neighbours, paving the way for the replacement of European mammals by Asian mammals.
Study of gene therapy treatment in Wiskott-Aldrich syndrome
Teams from the AP-HP, University of Paris, Inserm, within the Imagine Institute, the University College of London, and Généthon, have carried out work on treatment by gene therapy consisting of transplanting the patient's own genetically modified hematopoietic stem cells as part of a phase I/II clinical trial, promoted by Genethon, in 8 patients with Wiskott-Aldrich syndrome (WAS).
Teams from the AP-HP, University of Paris, Inserm, within the Imagine Institute, the University College of London, and Généthon, have carried out work on treatment by gene therapy consisting of transplanting the patient's own genetically modified hematopoietic stem cells as part of a phase I/II clinical trial, promoted by Genethon, in 8 patients with Wiskott-Aldrich syndrome (WAS).
In collaboration with a Canadian team, scientists from Inserm and Université de Tours, at Unit 1253 Imaging & Brain1, have shown in post-mortem brain samples that victims of child abuse present specific brain characteristics. The teams have revealed for the first time in humans an increase in the number and maturation of perineuronal nets, dense protein structures surrounding the neurons.
Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 years post-diagnosis. Proteasome inhibitors, the therapeutic backbone of current treatments, are very effective in treating newly diagnosed cancers but resistance or intolerance to these molecules inevitably develop, leading to relapses.
Shaking hands is an example of a social convention to say hello or goodbye. For the first time, scientists have studied the development of social conventions in non-human primates. Baboons, for example, can also establish conventions A research team from the CNRS and Aix-Marseille Université has demonstrated that members of a group of baboons can establish shared social conventions - in this case, by all agreeing on how to solve a problem in order to get a reward faster.
Coccolithophores are microscopic algae that form tiny limestone plates, called coccoliths, around their single cells. The shape and size of coccoliths varies according to the species. After their death, coccolithophores sink to the bottom of the ocean and their coccoliths accumulate in sediments, which faithfully record the detailed evolution of these organisms over geological time.
The modern horse was domesticated around 2200 years BCE in the northern Caucasus. In the centuries that followed it spread throughout Asia and Europe. To achieve this result, an international team of 162 scientists collected, sequenced and compared 273 genomes from ancient horses scattered across Eurasia.
Cell nuclei protect the DNA. Nuclei can rupture when cells are deformed, causing DNA damage. In the case of breast cancer, this damage makes tumour cells more invasive, with increased risk of metastasis. When cells multiply and migrate, they can be compressed and their nucleus may break open. This phenomenon causes DNA damage.
Career - May 24
Aix-Marseille University and all the partners of the A*Midex consortium celebrate 10 years of the Initiative of Excellence
Aix-Marseille University and all the partners of the A*Midex consortium celebrate 10 years of the Initiative of Excellence
Innovation - May 6
Launch of 3ALP, a public-private laboratory dedicated to the aluminium of the future
Launch of 3ALP, a public-private laboratory dedicated to the aluminium of the future