Materials Science - Nov 30
New collaborations between academic research and business to develop the high-performance batteries of the future
New collaborations between academic research and business to develop the high-performance batteries of the future
Health - Nov 28
YAP, protein involved in staphylococcus aureus infections, opens the door to new therapeutic strategies
YAP, protein involved in staphylococcus aureus infections, opens the door to new therapeutic strategies
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Life Sciences - Health - 01.12.2022 
ASD: Towards a Better Understanding of the Molecular Mechanisms of Autism
While great progress has been made in recent years in the understanding of autism spectrum disorder (ASD), its underlying molecular mechanisms remain fairly poorly documented.
Life Sciences - 23.11.2022
Health - Life Sciences - 22.11.2022 
A New Gene Therapy Strategy for Sickle Cell Disease and Beta-Thalassemia
Both sickle cell disease and beta-thalassemia are genetic disorders that affect hemoglobin, and as such are categorized as beta-hemoglobinopathies. A team of scientists from Inserm, Université Paris Cité and the Paris Public Hospitals Group AP-HP at the Imagine Institute has shown the efficacy of a gene therapy approach to treat these two disorders.
Life Sciences - Health - 21.11.2022 
Alzheimer’s disease: newly identified rare gene variants significantly increase the risk of developing this pathology
An international consortium has identified rare variants in two new genes that markedly increase the risk of developing Alzheimer's disease (AD). The work was led by two research groups in France (headed respectively by Gaël Nicolas, Rouen and Jean-Charles Lambert, Lille) and a group in the Netherlands (headed by Henne Holstege, Amsterdam).
Health - Life Sciences - 16.11.2022 
Fatty liver disease endangers brain health
People with liver disease caused by eating too much sugar and fat could be at increased risk of developing serious neurological conditions like depression or dementia. In a study examining the link between non-alcoholic fatty liver disease (NAFLD) and brain dysfunction, scientists at the Roger Williams Institute of Hepatology, affiliated to King's College London and the University of Lausanne, found an accumulation of fat in the liver causes a decrease in oxygen to the brain and inflammation to brain tissue - both of which have been proven to lead to the onset of severe brain diseases.
Health - Life Sciences - 15.11.2022 
A potential therapy to reduce the side effects of a chemotherapy
Cisplatin is a chemotherapy indicated to fight tumors in many types of cancer. However, it does have major side effects - especially kidney toxicity, that can lead to acute kidney failure. In addition, patients treated with cisplatin also often report high levels of neuropathic pain.
Innovation - Life Sciences - 20.10.2022 
How can flying insects and drones tell up from down?
A team of European researchers has established a new principle that explains how flying insects determine the direction of gravity, without using accelerometers. These results are an important step towards the creation of tiny autonomous drones. For proper operation, drones usually use accelerometers to determine the direction of gravity.
Life Sciences - Chemistry - 19.10.2022
Life Sciences - 11.10.2022 
In the brain of procrastinators
A team of researchers from Inserm, CNRS, Sorbonne University and AP-HP at the Brain Institute in Paris has just deciphered how our brain behaves when we procrastinate. The study, conducted in humans, combines functional imaging and behavioral tests and allowed scientists to identify a region of the brain where the decision to procrastinate is played out: the anterior cingulate cortex.
Psychology - Life Sciences - 10.10.2022
Life Sciences - Health - 05.10.2022 
Reducing long-term complications in infants born prematurely
Children born prematurely have a higher risk of suffering from cognitive and sensory disorders but also infertility in adulthood. In a new study, a team of researchers from Inserm, the University Hospital of Lille and the University of Lille, within the Lille Neuroscience and Cognition Laboratory, raises interesting avenues to improve their prognosis.
Life Sciences - 15.09.2022 
How does our brain react when we explore something new?
In a constantly changing world, making good decisions requires the ability to explore different strategies and to identify the one that will be the most appropriate. Research conducted by a team of neuroscientists from Inserm and CNRS at the École Normale Supérieure - PSL, in collaboration with Harvard University (USA), has made it possible to characterize this cognitive process by recording the tiny changes in the magnetic field emitted by the activity of the human brain.
Life Sciences - History / Archeology - 09.09.2022 
The origins of donkey domestication
The donkey has shaped the history of humankind, both as a source of power for farm work, and of transportation in sometimes hard to reach areas. To understand the history of the donkey's domestication, teams at the Centre for Anthropobiology and Genomics of Toulouse (CNRS/ Université Toulouse 3 Paul Sabatier) and scientists 1 from 37 laboratories around the world worked together to build and analyse the most complete panel of genomes ever studied for this animal.
Health - Life Sciences - 08.09.2022
Life Sciences - Health - 30.08.2022 
New therapeutic prospect for preeclampsia
Preeclampsia is a condition that affects the placenta during pregnancy and is dangerous for both the fetus and the mother. Scientists from the Institut Pasteur, Inserm and the CNRS have proposed a new therapy, tested in two rodent models, that corrects the defects identified in placental cells, and restores placental and fetal weight.
Paleontology - Life Sciences - 24.08.2022 
Sahelanthropus, the oldest representative of humanity, was indeed bipedal...but that’s not all!
The modalities and date of emergence of bipedalism remain bitterly debated, in particular because of a small number of very old human fossils. Sahelanthropus tchadensis , discovered in 2001 in Chad, is considered to be the oldest representative of the humankind. The shape of its cranium suggests a bipedal station.
Health - Life Sciences - 05.08.2022 
Functional ultrasound microscopy: probing the activity of the whole brain at the microscopic level
Ultrasound is transforming the field of neuroimaging, thanks to technological advances made over the last decade by the Physics for Medicine laboratory (Inserm, ESPCI Paris - PSL, CNRS). The introduction of functional ultrasound imaging (fUS) in 2009 provided neuroscientists with a unique technology - portable, easy to use, and reasonably priced - to visualize brain activity with high sensitivity.
Life Sciences - Physics - 29.07.2022 
Manipulating chromosomes in living cells reveals that they are fluid
Chromosomes are fluid - almost liquid - outside their division phases. This discovery was made possible thanks to the direct mechanical manipulation, for the very first time, of chromosomes in the nucleus of living cells. Until then, chromosomes - which are very long DNA molecules - were represented as being entangled like loose balls of yarn, and forming a sort of gel.
Life Sciences - Physics - 28.07.2022 
A ’Nano-Robot’ Built Entirely from DNA to Explore Cell Processes
Constructing a tiny robot from DNA and using it to study cell processes invisible to the naked eye. You would be forgiven for thinking it is science fiction, but it is in fact the subject of serious research by scientists from Inserm, CNRS and Université de Montpellier at the Structural Biology Center in Montpellier .
Life Sciences - 27.07.2022 
A methodological leap in the exploration of memory
Neurons communicate with each other across synapses, areas of close contact where neurotransmitter molecules released from one neuron act on receptors embedded in the membrane of the opposite neuron. Previous research conducted by the team of Daniel Choquet, researcher at the CNRS and Director of the Interdisciplinary Institute for Neurosciences (CNRS/University of Bordeaux) had discovered that these receptors are not stationary, but instead move constantly in the membrane.
Life Sciences
Results 1 - 20 of 295.
While great progress has been made in recent years in the understanding of autism spectrum disorder (ASD), its underlying molecular mechanisms remain fairly poorly documented.
How can bats harbor so many viruses without developing symptoms?
Bats are asymptomatic carriers of a multitude of viruses that are pathogenic to most other mammals. How has their immune system evolved to shield them from these pathogens? A team of scientists-the majority affiliated with the CNRS, Claude Bernard Lyon 1 University, and ENS de Lyon 1 - has just published an article in Science Advances addressing that question.
Bats are asymptomatic carriers of a multitude of viruses that are pathogenic to most other mammals. How has their immune system evolved to shield them from these pathogens? A team of scientists-the majority affiliated with the CNRS, Claude Bernard Lyon 1 University, and ENS de Lyon 1 - has just published an article in Science Advances addressing that question.
Both sickle cell disease and beta-thalassemia are genetic disorders that affect hemoglobin, and as such are categorized as beta-hemoglobinopathies. A team of scientists from Inserm, Université Paris Cité and the Paris Public Hospitals Group AP-HP at the Imagine Institute has shown the efficacy of a gene therapy approach to treat these two disorders.
An international consortium has identified rare variants in two new genes that markedly increase the risk of developing Alzheimer's disease (AD). The work was led by two research groups in France (headed respectively by Gaël Nicolas, Rouen and Jean-Charles Lambert, Lille) and a group in the Netherlands (headed by Henne Holstege, Amsterdam).
People with liver disease caused by eating too much sugar and fat could be at increased risk of developing serious neurological conditions like depression or dementia. In a study examining the link between non-alcoholic fatty liver disease (NAFLD) and brain dysfunction, scientists at the Roger Williams Institute of Hepatology, affiliated to King's College London and the University of Lausanne, found an accumulation of fat in the liver causes a decrease in oxygen to the brain and inflammation to brain tissue - both of which have been proven to lead to the onset of severe brain diseases.
Cisplatin is a chemotherapy indicated to fight tumors in many types of cancer. However, it does have major side effects - especially kidney toxicity, that can lead to acute kidney failure. In addition, patients treated with cisplatin also often report high levels of neuropathic pain.
A team of European researchers has established a new principle that explains how flying insects determine the direction of gravity, without using accelerometers. These results are an important step towards the creation of tiny autonomous drones. For proper operation, drones usually use accelerometers to determine the direction of gravity.
How can digital data stored as DNA be manipulated?
Data can be encoded as DNA but are difficult to process thereafter. A new method enables operations to be performed on DNA-encoded data directly, without having to first translate them into their electronic equivalent. DNA can be used to reliably store a vast amount of digital data. However, retrieval or manipulation of specific data encoded in these molecules has hitherto been difficult.
Data can be encoded as DNA but are difficult to process thereafter. A new method enables operations to be performed on DNA-encoded data directly, without having to first translate them into their electronic equivalent. DNA can be used to reliably store a vast amount of digital data. However, retrieval or manipulation of specific data encoded in these molecules has hitherto been difficult.
A team of researchers from Inserm, CNRS, Sorbonne University and AP-HP at the Brain Institute in Paris has just deciphered how our brain behaves when we procrastinate. The study, conducted in humans, combines functional imaging and behavioral tests and allowed scientists to identify a region of the brain where the decision to procrastinate is played out: the anterior cingulate cortex.
Preventing dementia in seniors: meditation still under investigation
Meditation as a tool to prevent dementia and improve the mental health and well-being of elderly people is one of the avenues explored by the European Medit-Ageing research program, coordinated by Inserm. As part of this program, researchers from Inserm and Université de Caen Normandie, in collaboration with French and European teams, observed the impact of 18 months of meditation training on certain brain structures involved in regulating attention and emotions in healthy people over 65.
Meditation as a tool to prevent dementia and improve the mental health and well-being of elderly people is one of the avenues explored by the European Medit-Ageing research program, coordinated by Inserm. As part of this program, researchers from Inserm and Université de Caen Normandie, in collaboration with French and European teams, observed the impact of 18 months of meditation training on certain brain structures involved in regulating attention and emotions in healthy people over 65.
Children born prematurely have a higher risk of suffering from cognitive and sensory disorders but also infertility in adulthood. In a new study, a team of researchers from Inserm, the University Hospital of Lille and the University of Lille, within the Lille Neuroscience and Cognition Laboratory, raises interesting avenues to improve their prognosis.
In a constantly changing world, making good decisions requires the ability to explore different strategies and to identify the one that will be the most appropriate. Research conducted by a team of neuroscientists from Inserm and CNRS at the École Normale Supérieure - PSL, in collaboration with Harvard University (USA), has made it possible to characterize this cognitive process by recording the tiny changes in the magnetic field emitted by the activity of the human brain.
The donkey has shaped the history of humankind, both as a source of power for farm work, and of transportation in sometimes hard to reach areas. To understand the history of the donkey's domestication, teams at the Centre for Anthropobiology and Genomics of Toulouse (CNRS/ Université Toulouse 3 Paul Sabatier) and scientists 1 from 37 laboratories around the world worked together to build and analyse the most complete panel of genomes ever studied for this animal.
COVID-19: Keys to the disease in the past of primate and bat genes?
Publication of the CIRI in the journal PNAS . CNRS-INSB communication on September 7, 2022. The coronavirus disease 19 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a coronavirus that spilled over from the bat reservoir. Despite numerous clinical trials and vaccines, the burden remains immense, and the host determinants of SARS-CoV-2 susceptibility and COVID-19 severity remain largely unknown.
Publication of the CIRI in the journal PNAS . CNRS-INSB communication on September 7, 2022. The coronavirus disease 19 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a coronavirus that spilled over from the bat reservoir. Despite numerous clinical trials and vaccines, the burden remains immense, and the host determinants of SARS-CoV-2 susceptibility and COVID-19 severity remain largely unknown.
Preeclampsia is a condition that affects the placenta during pregnancy and is dangerous for both the fetus and the mother. Scientists from the Institut Pasteur, Inserm and the CNRS have proposed a new therapy, tested in two rodent models, that corrects the defects identified in placental cells, and restores placental and fetal weight.
The modalities and date of emergence of bipedalism remain bitterly debated, in particular because of a small number of very old human fossils. Sahelanthropus tchadensis , discovered in 2001 in Chad, is considered to be the oldest representative of the humankind. The shape of its cranium suggests a bipedal station.
Ultrasound is transforming the field of neuroimaging, thanks to technological advances made over the last decade by the Physics for Medicine laboratory (Inserm, ESPCI Paris - PSL, CNRS). The introduction of functional ultrasound imaging (fUS) in 2009 provided neuroscientists with a unique technology - portable, easy to use, and reasonably priced - to visualize brain activity with high sensitivity.
Chromosomes are fluid - almost liquid - outside their division phases. This discovery was made possible thanks to the direct mechanical manipulation, for the very first time, of chromosomes in the nucleus of living cells. Until then, chromosomes - which are very long DNA molecules - were represented as being entangled like loose balls of yarn, and forming a sort of gel.
Constructing a tiny robot from DNA and using it to study cell processes invisible to the naked eye. You would be forgiven for thinking it is science fiction, but it is in fact the subject of serious research by scientists from Inserm, CNRS and Université de Montpellier at the Structural Biology Center in Montpellier .
Neurons communicate with each other across synapses, areas of close contact where neurotransmitter molecules released from one neuron act on receptors embedded in the membrane of the opposite neuron. Previous research conducted by the team of Daniel Choquet, researcher at the CNRS and Director of the Interdisciplinary Institute for Neurosciences (CNRS/University of Bordeaux) had discovered that these receptors are not stationary, but instead move constantly in the membrane.
Materials Science - Nov 30
New collaborations between academic research and business to develop the high-performance batteries of the future
New collaborations between academic research and business to develop the high-performance batteries of the future
Health - Nov 28
YAP, protein involved in staphylococcus aureus infections, opens the door to new therapeutic strategies
YAP, protein involved in staphylococcus aureus infections, opens the door to new therapeutic strategies