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Life Sciences - Pharmacology - 22.05.2024
Hallucinogenic mushrooms to treat alcohol addiction
Hallucinogenic mushrooms to treat alcohol addiction
A ground-breaking study conducted by INSERM's Groupe de Recherches sur l'Alcool et les Pharmacodépendances (GRAP) opens up new therapeutic perspectives for the treatment of alcohol addiction with psilocybin, the active compound in hallucinogenic mushrooms. Published in the scientific journal Brain , their work confirms the potential of psilocybin to combat alcohol addiction, while shedding light on the molecule's hitherto unknown mechanisms of action.

Health - Pharmacology - 21.05.2024
Tuberculosis: a new lead for biomarkers to assess the risk of transmission
Tuberculosis is the second leading cause of death from infectious disease in the world after COVID-19. Scientists from INRAE and Inserm have discovered two subsets of neutrophils that play opposing roles in inflammatory responses to infection and could serve as biomarkers to identify individuals at risk of developing a contagious form of the disease.

Health - Pharmacology - 13.05.2024
Cancer spread: targeting platelets to counter metastasis?
Scanning electron microscopy. Here we see how platelets (in blue/purple) attach to two tumour cells (in red) in a pre-clinical mouse model. Maria Jesus Garcia Leon (unit 1109 Inserm/Université de Strasbourg) What if our blood platelets , which play a major role in maintaining the integrity of our circulatory system, were not always on our side' Research teams from Inserm, Université de Strasbourg and the French Blood Establishment have studied their role in the process of metastasis formation.

Health - Pharmacology - 17.04.2024
Preventing cardiovascular risk thanks to a tool for measuring arterial stiffness
Cardiovascular diseases represent the leading cause of death worldwide . Preventing cardiovascular risk by identifying the people most susceptible to these diseases is a major public health challenge. In a new study in this field, researchers from Inserm, Université de Lorraine and Nancy Regional University Hospital opted to focus on arterial stiffness and how it changes with age, given that ageing is associated with a loss of arterial flexibility.

Health - Pharmacology - 10.04.2024
Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
Inflammation plays a major role in allergic diseases, affecting at least 17 million people in France, including 4 million asthmatics. One of the molecules that initiates this process in the respiratory tract has just been identified. This molecule, a member of the alarmin family, is a major therapeutic target for the development of new treatments for respiratory allergies.

Health - Pharmacology - 11.03.2024
A promising vaccine against Nipah virus infection
A promising vaccine against Nipah virus infection
The WHO recently classified the Nipah virus (NiV) as one of the eight main emerging pathogens likely to cause major epidemics in the future. In a context where no treatment or vaccine is yet available, a team comprising researchers from Inserm (Unit 955-VRI) and from the Université Paris-Est Créteil (UPEC) is presenting the preclinical results of an innovative vaccine against this virus.

Health - Pharmacology - 15.02.2024
New therapeutic avenues to improve ovarian cancer treatment
New therapeutic avenues to improve ovarian cancer treatment
By studying for the first time the effects of chemotherapy on certain cells in the tumor microenvironment , a team from the Institut Curie and Inserm, led by Dr. Fatima Mechta-Grigoriou, has taken a major step towards understanding the mechanisms of chemotherapy resistance in ovarian cancer patients.

Health - Pharmacology - 24.11.2023
Effective non-invasive ultrasound therapy in the treatment of heart valve diseases
Effective non-invasive ultrasound therapy in the treatment of heart valve diseases
Adobe stock Currently, the treatment of heart valve diseases relies on the replacement of the dysfunctional valve with an artificial prosthesis. However, this procedure cannot be offered to all patients due to its invasive nature.

Pharmacology - Life Sciences - 28.08.2023
A major step forward in the treatment of narcolepsy
A major step forward in the treatment of narcolepsy
Difficulty staying awake may seem trivial, but it's the main symptom of one of the most severe sleep disorders: narcolepsy. In Montpellier, the Centre de référence des narcolepsies et hypersomnies rares (Inserm/University/CHU de Montpellier) headed by Yves Dauvilliers is conducting cutting-edge research into this disease.

Health - Pharmacology - 27.07.2023
Remission from HIV-1 infection: discovery of broadly neutralizing antibodies that contribute to virus control
Remission from HIV-1 infection: discovery of broadly neutralizing antibodies that contribute to virus control
Antibody fragments of EPCT112 bNAb (blue) discovered at the Institut Pasteur by Hugo Mouquet's team, here forming a complex with the HIV-1 envelope protein (Env) (shown in yellow and orange Some HIV-1 carriers who have received an early antiretroviral treatment during several years are able to control the virus for a long term after treatment interruption.

Health - Pharmacology - 11.07.2023
A global overview of antibiotic resistance determinants
A global overview of antibiotic resistance determinants
To understand the main determinants behind worldwide antibiotic resistance dynamics, scientists from the Institut Pasteur, Inserm, Université de Versailles Saint-Quentin-en-Yvelines and Université Paris-Saclay developed a statistical model based on a large-scale spatial-temporal analysis. Using the ATLAS antimicrobial resistance surveillance database, the model revealed significant differences in trends and associated factors depending on bacterial species and resistance to certain antibiotics.

Health - Pharmacology - 23.05.2023
A marine worm, life saver
A marine worm, life saver
In 2020, in the midst of the COVID-19 crisis, we spoke with Franck Zal, a doctor in marine biology from Sorbonne University and founder of the company Hemarina. At the time, HEMO2life - their flagship product created from the hemoglobin of the marine worm, the arenicole - was envisaged to improve the oxygenation of patients suffering from acute respiratory distress syndrome.

Health - Pharmacology - 11.04.2023
A New Target to Regress Liver Fibrosis
Cirrhosis is the final stage of fibrosis associated with chronic liver diseases. It affects 200,000 to 500,000 individuals in France and is responsible for 170,000 deaths per year in Europe. Adobe Stock Chronic liver diseases are characterized by persistent inflammation that contributes to their progression to more severe stages.

Health - Pharmacology - 23.03.2023
Covid-19: infection-vaccination combination best protects against reinfection with SARS-CoV-2
Publication of the CIRI in the journal Science Translational Medicine on March 15, 2023. Press realease of the INSERM on March 17, 2023. A large proportion of the population has developed immunity to SARS-CoV-2 following infection and/or vaccination. In addition, some infected patients benefit from a so-called "hybrid" immunity when they have been vaccinated after their infectious episode.

Health - Pharmacology - 21.03.2023
COVID-19: Infection-Vaccination is the Most Protective Combination Against Reinfection
A large part of the population has developed immunity against SARS-CoV-2 following infection, vaccination - or both. In addition, some infected patients enjoy "hybrid” immunity when they are vaccinated following their infectious episode. Scientists from Inserm, CNRS, Université Claude-Bernard Lyon 1 and ENS de Lyon at the International Center for Research on Infectious Diseases (CIRI) seek to characterize the imprint left by SARS-CoV-2 exposure through vaccination or the combination of the two events on immune memory.

Health - Pharmacology - 14.03.2023
Pancreatic cancer: discovery of a molecular test allows for personalized treatment
Inserm researchers at the Marseille Cancer Research Center (CRCM - AMU/Inserm/CNRS/IPC) and clinicians at the Paoli-Calmettes Institute (IPC) have identified a molecular test for personalized treatment of pancreatic cancer. This new strategy, based on the prediction of the sensitivity of each patient to the different chemotherapy protocols currently available, opens the way to personalized treatments for pancreatic cancer.

Health - Pharmacology - 07.03.2023
A New Milestone in the Development of an Effective Allergic Asthma Vaccine
To combat allergic asthma, which affects millions of people worldwide, scientists from Inserm, CNRS and Université Toulouse III-Paul Sabatier at the Infinity laboratory , Institut Pasteur and French company NEOVACS are developing and testing a new vaccine. In their previous study, the teams had shown it to be effective in producing antibodies capable of neutralizing human immune proteins that play a key role in triggering allergic asthma, cytokines IL-4 and IL-13.

Health - Pharmacology - 20.02.2023
Obesity and overweight: nearly one French person in two is affected
Obesity and overweight: nearly one French person in two is affected
Obesity is a global public health problem with an increasing incidence. According to the WHO, since 1975, the number of obesity cases has almost tripled worldwide . Obesity is associated with numerous comorbidities and high mortality. It is estimated that this complex chronic disease increases the risk of cardiovascular disease (first cause of death in the world), diabetes, musculoskeletal disorders, many forms of cancer (endometrial, breast, ovarian, prostate, liver, gallbladder, kidney and colon.

Health - Pharmacology - 17.02.2023
Better understand the transition from acute to chronic pain
Better understand the transition from acute to chronic pain
Researchers from the University of Montpellier and Inserm at the Montpellier Neuroscience Institute have shown the preponderant role of the FLT3 receptor in chronic post-surgical pain. By inhibiting this receptor with therapeutic antibodies, the scientists could propose promising avenues for the prevention of chronic pain.

Health - Pharmacology - 17.01.2023
Immunotherapy: a new two-in-one weapon against resistant tumors
Immunotherapy: a new two-in-one weapon against resistant tumors
Pressing the gas pedal and lifting the brake at the same time is the innovative idea of Dr. Nicolas Manel, Inserm researcher and team leader at the Institut Curie (Immunity and Cancer Unit - Institut Curie, Inserm) to improve the response to immunotherapies. For several years, the researchers have identified a signaling pathway - STING - that is essential for accelerating the response to immunotherapies.
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