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Life Sciences - Health - 01.12.2022
ASD: Towards a Better Understanding of the Molecular Mechanisms of Autism
ASD: Towards a Better Understanding of the Molecular Mechanisms of Autism
While great progress has been made in recent years in the understanding of autism spectrum disorder (ASD), its underlying molecular mechanisms remain fairly poorly documented.

Health - 24.11.2022
Tuberculosis: children hospitalized with severe pneumonia in high-incidence countries should be screened for TB
Tuberculosis: children hospitalized with severe pneumonia in high-incidence countries should be screened for TB
Tuberculosis affects 1 million children each year; less than half of them are diagnosed and treated for the disease, which leads to more than 200,000 deaths.

Health - Life Sciences - 22.11.2022
A New Gene Therapy Strategy for Sickle Cell Disease and Beta-Thalassemia
A New Gene Therapy Strategy for Sickle Cell Disease and Beta-Thalassemia
Both sickle cell disease and beta-thalassemia are genetic disorders that affect hemoglobin, and as such are categorized as beta-hemoglobinopathies. A team of scientists from Inserm, Université Paris Cité and the Paris Public Hospitals Group AP-HP at the Imagine Institute has shown the efficacy of a gene therapy approach to treat these two disorders.

Life Sciences - Health - 21.11.2022
Alzheimer's disease: newly identified rare gene variants significantly increase the risk of developing this pathology
Alzheimer’s disease: newly identified rare gene variants significantly increase the risk of developing this pathology
An international consortium has identified rare variants in two new genes that markedly increase the risk of developing Alzheimer's disease (AD). The work was led by two research groups in France (headed respectively by Gaël Nicolas, Rouen and Jean-Charles Lambert, Lille) and a group in the Netherlands (headed by Henne Holstege, Amsterdam).

Health - Life Sciences - 16.11.2022
Fatty liver disease endangers brain health
Fatty liver disease endangers brain health
People with liver disease caused by eating too much sugar and fat could be at increased risk of developing serious neurological conditions like depression or dementia. In a study examining the link between non-alcoholic fatty liver disease (NAFLD) and brain dysfunction, scientists at the Roger Williams Institute of Hepatology, affiliated to King's College London and the University of Lausanne, found an accumulation of fat in the liver causes a decrease in oxygen to the brain and inflammation to brain tissue - both of which have been proven to lead to the onset of severe brain diseases.

Health - Life Sciences - 15.11.2022
A potential therapy to reduce the side effects of a chemotherapy
A potential therapy to reduce the side effects of a chemotherapy
Cisplatin is a chemotherapy indicated to fight tumors in many types of cancer. However, it does have major side effects - especially kidney toxicity, that can lead to acute kidney failure. In addition, patients treated with cisplatin also often report high levels of neuropathic pain.

Health - Pharmacology - 09.11.2022
Long COVID: A Dysregulated Immune Response Could Explain Symptoms Persistence
Long COVID: A Dysregulated Immune Response Could Explain Symptoms Persistence
Several months after SARS-CoV-2 infection, some patients continue to have symptoms. This phenomenon, known as "post-COVID condition” or, more commonly, "long COVID”, remains poorly documented. In order to address this and improve patient care, research teams are trying to improve their understanding of the underlying biological and immunological mechanisms.

Health - 24.10.2022
Efficacy of a Meningococcal B Vaccine and a Preventive Antibiotic in Reducing the Risk of Sexually Transmitted Infections
The ANRS DOXYVAC trial, conducted by a research team from the Paris public hospitals group (AP-HP), Université Paris Cité, Inserm and Sorbonne Université in collaboration with AIDES and Coalition PLUS, demonstrates the efficacy of both a meningococcal B vaccine in reducing the risk of gonorrhea infection and the use of doxycycline as preventive intervention for sexually transmitted infections when taken within 72h after sexual intercourse.

Health - 18.10.2022
Short nights of sleep from the age of 50 increase the risk of developing several chronic diseases
More than half of adults over age 65 have two or more chronic conditions. Multimorbidity, or the presence of multiple chronic conditions in the same person, is a major public health challenge. While the scientific literature has provided consistent evidence of an association between sleep duration and the risk of developing various chronic diseases such as cardiovascular disease and cancer, no study had previously focused on the link between sleep and multimorbidity.

Health - 14.10.2022
Testosterone is an ally of macrophages in the battle against adrenal cancers
Testosterone is an ally of macrophages in the battle against adrenal cancers
Why are cancers of the adrenal glands 1  more common among women? Why are prognoses worse for them? A team of scientists led by a CNRS researcher answers these questions in an article published on 14 October 2022 in Science Advances . They demonstrate that, in male mice, there is greater recruitment of immune cells known as macrophages, which can eliminate tumour cells.

Life Sciences - Health - 05.10.2022
Reducing long-term complications in infants born prematurely
Reducing long-term complications in infants born prematurely
Children born prematurely have a higher risk of suffering from cognitive and sensory disorders but also infertility in adulthood. In a new study, a team of researchers from Inserm, the University Hospital of Lille and the University of Lille, within the Lille Neuroscience and Cognition Laboratory, raises interesting avenues to improve their prognosis.

Pharmacology - Health - 04.10.2022
Chemotherapy: towards a simplified subcutaneous administration
Chemotherapy: towards a simplified subcutaneous administration
The treatment of cancer is often based on intravenous chemotherapy, which is highly demanding and requires hospitalisation. One of the possibilities considered to alleviate this protocol is subcutaneous chemotherapy. Though much simpler to implement and more comfortable for the patient, it is impossible to practice as most of the active ingredients administered are irritant and vesicant - they stagnate in the subcutaneous tissue where they cause skin necrosis due to their high toxicity.

Health - 23.09.2022
At what stage(s) after infection are memory CD8 T cells generated?
Publication of the CIRI and the LBMC in the journal iScience on September 16, 2022. CNRS-INSB communication on September 22, 2022. The stage at which memory CD8 T cells diverge after a viral infection remains debated. These cells are essential for effective protection of individuals during subsequent infection.

Health - Life Sciences - 08.09.2022
COVID-19: Keys to the disease in the past of primate and bat genes?
Publication of the CIRI in the journal PNAS . CNRS-INSB communication on September 7, 2022. The coronavirus disease 19 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a coronavirus that spilled over from the bat reservoir. Despite numerous clinical trials and vaccines, the burden remains immense, and the host determinants of SARS-CoV-2 susceptibility and COVID-19 severity remain largely unknown.

Health - Agronomy / Food Science - 08.09.2022
Artificial Sweeteners: Possible Link to Increased Cardiovascular Disease Risk
Artificial Sweeteners: Possible Link to Increased Cardiovascular Disease Risk
Cardiovascular diseases are the leading cause of death worldwide. Identifying the risk factors associated with these diseases in order to better prevent them represents a real public health challenge. A group of researchers from Inserm, INRAE, Cnam and Université Sorbonne Paris Nord within the Nutritional epidemiology research team (Eren) studied the health impacts of artificial sweetener consumption.

Life Sciences - Health - 30.08.2022
New therapeutic prospect for preeclampsia
New therapeutic prospect for preeclampsia
Preeclampsia is a condition that affects the placenta during pregnancy and is dangerous for both the fetus and the mother. Scientists from the Institut Pasteur, Inserm and the CNRS have proposed a new therapy, tested in two rodent models, that corrects the defects identified in placental cells, and restores placental and fetal weight.

Social Sciences - Health - 24.08.2022
High Temperatures Have Short-Term Impact on All Major Causes of Death, Including Suicide
High Temperatures Have Short-Term Impact on All Major Causes of Death, Including Suicide
Temperature and mortality are linked. There is a short-term increase in mortality when temperatures are at their hottest or coldest - a phenomenon known as a "U-shaped relationship”.

Health - Life Sciences - 05.08.2022
Functional ultrasound microscopy: probing the activity of the whole brain at the microscopic level
Functional ultrasound microscopy: probing the activity of the whole brain at the microscopic level
Ultrasound is transforming the field of neuroimaging, thanks to technological advances made over the last decade by the Physics for Medicine laboratory (Inserm, ESPCI Paris - PSL, CNRS). The introduction of functional ultrasound imaging (fUS) in 2009 provided neuroscientists with a unique technology - portable, easy to use, and reasonably priced - to visualize brain activity with high sensitivity.

Health - Life Sciences - 20.07.2022
Pain Intensity Is Controlled by Our Internal Clock
As with many of the body's functions, pain intensity is controlled by our internal clock. This is what a team of Inserm researchers at the Lyon Neuroscience Research Center (Inserm/Université Claude Bernard Lyon 1/CNRS) has recently discovered. They show that pain oscillates over 24 hours with a peak at night and a decrease in the afternoon, regardless of the sleep-wake cycle or any external stimulation.

Psychology - Health - 18.07.2022
Online mindfulness meditation practice effective in improving mental health of confined students
Online mindfulness meditation practice effective in improving mental health of confined students
This study by scientists at the Institut des sciences du mouvement Etienne-Jules Marey (CNRS/Aix-Marseille Université) reveals students' psychological distress during COVID-19-related lockdown and distance learning, as well as the effectiveness of an online mindfulness meditation practice in countering it.
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